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Nuclear export dynamics of RNA–protein complexes

Author

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  • David Grünwald

    (Delft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, 2628 CJ Delft, The Netherlands.)

  • Robert H. Singer

    (Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine)

  • Michael Rout

    (The Rockefeller University)

Abstract

The central dogma of molecular biology — DNA makes RNA makes proteins — is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

Suggested Citation

  • David Grünwald & Robert H. Singer & Michael Rout, 2011. "Nuclear export dynamics of RNA–protein complexes," Nature, Nature, vol. 475(7356), pages 333-341, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7356:d:10.1038_nature10318
    DOI: 10.1038/nature10318
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    Cited by:

    1. Liang Chen & Yucong Wang & Jiamei Lin & Zhenxing Song & Qinwei Wang & Wenfang Zhao & Yan Wang & Xiaoyu Xiu & Yuqi Deng & Xiuzhi Li & Qiqi Li & Xiaolin Wang & Jingxin Li & Xu Liu & Kunpeng Liu & Jincon, 2022. "Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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