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Dynamic molecular processes mediate cellular mechanotransduction

Author

Listed:
  • Brenton D. Hoffman

    (Robert M. Berne Cardiovascular Research Center, University of Virginia)

  • Carsten Grashoff

    (Robert M. Berne Cardiovascular Research Center, University of Virginia)

  • Martin A. Schwartz

    (Robert M. Berne Cardiovascular Research Center, University of Virginia
    University of Virginia
    University of Virginia)

Abstract

Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion complexes and the cytoskeleton. Recent work has demonstrated that these structures are dynamic, undergoing assembly, disassembly and movement, even when ostensibly stable. An emerging insight is that transduction of forces into biochemical signals occurs within the context of these processes. This framework helps to explain how forces of varying strengths or dynamic characteristics regulate distinct signalling pathways.

Suggested Citation

  • Brenton D. Hoffman & Carsten Grashoff & Martin A. Schwartz, 2011. "Dynamic molecular processes mediate cellular mechanotransduction," Nature, Nature, vol. 475(7356), pages 316-323, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7356:d:10.1038_nature10316
    DOI: 10.1038/nature10316
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    Citations

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    Cited by:

    1. C. Arbore & M. Sergides & L. Gardini & G. Bianchi & A. V. Kashchuk & I. Pertici & P. Bianco & F. S. Pavone & M. Capitanio, 2022. "α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Sorosh Amiri & Camelia Muresan & Xingbo Shang & Clotilde Huet-Calderwood & Martin A. Schwartz & David A. Calderwood & Michael Murrell, 2023. "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Venkat R. Chirasani & Mohammad Ashhar I. Khan & Juilee N. Malavade & Nikolay V. Dokholyan & Brenton D. Hoffman & Sharon L. Campbell, 2023. "Molecular basis and cellular functions of vinculin-actin directional catch bonding," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Jérôme R D Soiné & Christoph A Brand & Jonathan Stricker & Patrick W Oakes & Margaret L Gardel & Ulrich S Schwarz, 2015. "Model-based Traction Force Microscopy Reveals Differential Tension in Cellular Actin Bundles," PLOS Computational Biology, Public Library of Science, vol. 11(3), pages 1-16, March.
    5. Behruz Bozorg & Pawel Krupinski & Henrik Jönsson, 2014. "Stress and Strain Provide Positional and Directional Cues in Development," PLOS Computational Biology, Public Library of Science, vol. 10(1), pages 1-13, January.

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