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Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

Author

Listed:
  • Garret D. Stuber

    (UNC Neuroscience Center, University of North Carolina at Chapel Hill
    Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Dennis R. Sparta

    (UNC Neuroscience Center, University of North Carolina at Chapel Hill
    Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Alice M. Stamatakis

    (UNC Neuroscience Center, University of North Carolina at Chapel Hill)

  • Wieke A. van Leeuwen

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Juanita E. Hardjoprajitno

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Saemi Cho

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Kay M. Tye

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco
    Stanford University)

  • Kimberly A. Kempadoo

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco)

  • Feng Zhang

    (Stanford University)

  • Karl Deisseroth

    (Stanford University)

  • Antonello Bonci

    (Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Drug Addiction, University of California San Francisco
    Intramural Research Program, National Institute on Drug Abuse)

Abstract

Brain function during reward seeking Interactions between the basolateral amygdala (BLA) and nucleus accumbens (NAc) are involved in a number of reward-processing and addictive behaviours, but our understanding of the precise role of each of these brain areas has been limited by the inability to manipulate pathways selectively during behaviour. Stuber et al. use optogenetic technologies, in which light selectively activates or inhibits genetically-defined neuronal subpopulations, to reveal an unexpected role for the BLA — a brain region usually associated with aversive behaviours. The BLA is shown to be important for processing both positive and negative effects, but glutamatergic pathways between the BLA and NAc are specifically associated with reward-seeking behaviours.

Suggested Citation

  • Garret D. Stuber & Dennis R. Sparta & Alice M. Stamatakis & Wieke A. van Leeuwen & Juanita E. Hardjoprajitno & Saemi Cho & Kay M. Tye & Kimberly A. Kempadoo & Feng Zhang & Karl Deisseroth & Antonello , 2011. "Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking," Nature, Nature, vol. 475(7356), pages 377-380, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7356:d:10.1038_nature10194
    DOI: 10.1038/nature10194
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    Cited by:

    1. Kelsey M. Vollmer & Lisa M. Green & Roger I. Grant & Kion T. Winston & Elizabeth M. Doncheck & Christopher W. Bowen & Jacqueline E. Paniccia & Rachel E. Clarke & Annika Tiller & Preston N. Siegler & B, 2022. "An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Matthew T. Birnie & Annabel K. Short & Gregory B. Carvalho & Lara Taniguchi & Benjamin G. Gunn & Aidan L. Pham & Christy A. Itoga & Xiangmin Xu & Lulu Y. Chen & Stephen V. Mahler & Yuncai Chen & Talli, 2023. "Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. In Bum Lee & Eugene Lee & Na-Eun Han & Marko Slavuj & Jeong Wook Hwang & Ahrim Lee & Taeyoung Sun & Yehwan Jeong & Ja-Hyun Baik & Jae-Yong Park & Se-Young Choi & Jeehyun Kwag & Bong-June Yoon, 2024. "Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Oliver Barnstedt & Petra Mocellin & Stefan Remy, 2024. "A hippocampus-accumbens code guides goal-directed appetitive behavior," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Li Shen & Guang-Wei Zhang & Can Tao & Michelle B. Seo & Nicole K. Zhang & Junxiang J. Huang & Li I. Zhang & Huizhong W. Tao, 2022. "A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Kuikui Zhou & Hua Xu & Shanshan Lu & Shaolei Jiang & Guoqiang Hou & Xiaofei Deng & Miao He & Yingjie Zhu, 2022. "Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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