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Low-energy control of electrical turbulence in the heart

Author

Listed:
  • Stefan Luther

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Cornell University
    Institute for Nonlinear Dynamics, Georg August University, Am Fassberg 17
    Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40)

  • Flavio H. Fenton

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Cornell University)

  • Bruce G. Kornreich

    (Cornell University)

  • Amgad Squires

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Laboratory of Atomic and Solid State Physics, Cornell University)

  • Philip Bittihn

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Institute for Nonlinear Dynamics, Georg August University, Am Fassberg 17)

  • Daniel Hornung

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Institute for Nonlinear Dynamics, Georg August University, Am Fassberg 17)

  • Markus Zabel

    (Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40
    University Medical Center (UMG), Robert-Koch-Strasse 40)

  • James Flanders

    (Cornell University)

  • Andrea Gladuli

    (Cornell University)

  • Luis Campoy

    (Cornell University)

  • Elizabeth M. Cherry

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Cornell University
    School of Mathematical Sciences, Rochester Institute of Technology)

  • Gisa Luther

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Institute for Nonlinear Dynamics, Georg August University, Am Fassberg 17)

  • Gerd Hasenfuss

    (Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40
    University Medical Center (UMG), Robert-Koch-Strasse 40)

  • Valentin I. Krinsky

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Institut Non-Linéaire de Nice)

  • Alain Pumir

    (Laboratoire de Physique de l’Ecole Normale Supérieure de Lyon, Université Lyon 1 and CNRS)

  • Robert F. Gilmour

    (Cornell University)

  • Eberhard Bodenschatz

    (Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
    Institute for Nonlinear Dynamics, Georg August University, Am Fassberg 17
    Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40
    Laboratory of Atomic and Solid State Physics, Cornell University)

Abstract

Towards safer heart resuscitation Cardiac defibrillation is usually achieved using a single high-energy electric shock of up to 4,000 volts, which can be damaging to the heart tissue. Eberhard Bodenschatz and colleagues show how the disordered electrical dynamics that underlie cardiac fibrillation can be controlled using low-energy electrical pulses. They show, in tests on dogs, that intrinsic homogeneities in the cardiac tissue (such as the vasculature) serve as nucleation sites for the generation of waves of electrical activity that can target the instabilities and bring the tissue dynamics back into synchrony. The new technique, called low-energy antifibrillation pacing or LEAP, delivers five sequential low-energy electrical field pulses to the fibrillating heart — an average energy reduction of 84% compared to standard defibrillation.

Suggested Citation

  • Stefan Luther & Flavio H. Fenton & Bruce G. Kornreich & Amgad Squires & Philip Bittihn & Daniel Hornung & Markus Zabel & James Flanders & Andrea Gladuli & Luis Campoy & Elizabeth M. Cherry & Gisa Luth, 2011. "Low-energy control of electrical turbulence in the heart," Nature, Nature, vol. 475(7355), pages 235-239, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7355:d:10.1038_nature10216
    DOI: 10.1038/nature10216
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    Cited by:

    1. William A. Ramírez & Alessio Gizzi & Kevin L. Sack & Simonetta Filippi & Julius M. Guccione & Daniel E. Hurtado, 2020. "On the Role of Ionic Modeling on the Signature of Cardiac Arrhythmias for Healthy and Diseased Hearts," Mathematics, MDPI, vol. 8(12), pages 1-19, December.
    2. Mussa Juane, Mariamo & García-Selfa, David & Muñuzuri, Alberto P., 2020. "Turing instability in nonlinear chemical oscillators coupled via an active medium," Chaos, Solitons & Fractals, Elsevier, vol. 133(C).
    3. Ding, Qianming & Wu, Yong & Hu, Yipeng & Liu, Chaoyue & Hu, Xueyan & Jia, Ya, 2023. "Tracing the elimination of reentry spiral waves in defibrillation: Temperature effects," Chaos, Solitons & Fractals, Elsevier, vol. 174(C).

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