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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Author

Listed:
  • Andrea Facciabene

    (Ovarian Cancer Research Center, University of Pennsylvania)

  • Xiaohui Peng

    (Ovarian Cancer Research Center, University of Pennsylvania)

  • Ian S. Hagemann

    (University of Pennsylvania)

  • Klara Balint

    (Ovarian Cancer Research Center, University of Pennsylvania)

  • Andrea Barchetti

    (Ovarian Cancer Research Center, University of Pennsylvania)

  • Li-Ping Wang

    (University of Pennsylvania)

  • Phyllis A. Gimotty

    (University of Pennsylvania)

  • C. Blake Gilks

    (University of British Columbia, Vancouver)

  • Priti Lal

    (University of Pennsylvania)

  • Lin Zhang

    (Ovarian Cancer Research Center, University of Pennsylvania)

  • George Coukos

    (Ovarian Cancer Research Center, University of Pennsylvania)

Abstract

Immune tolerance and angiogenesis in tumour growth Regulatory T (Treg) cells are an important immunosuppressive lymphocyte population implicated in peripheral tolerance and in the pathogenesis of autoimmunity and cancer. The mechanisms accounting for Treg cell accumulation in tumours, and the precise mechanisms through which Treg cells contribute to tumour progression, are not fully understood. Facciabene et al. show that the chemokine CCL28 recruits Treg cells to hypoxic tumours, where they secrete VEGF-A and contribute to tumour angiogenesis. These findings suggest that tumour immune tolerance and angiogenesis are closely linked and may act together in promoting tumour growth.

Suggested Citation

  • Andrea Facciabene & Xiaohui Peng & Ian S. Hagemann & Klara Balint & Andrea Barchetti & Li-Ping Wang & Phyllis A. Gimotty & C. Blake Gilks & Priti Lal & Lin Zhang & George Coukos, 2011. "Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells," Nature, Nature, vol. 475(7355), pages 226-230, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7355:d:10.1038_nature10169
    DOI: 10.1038/nature10169
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    Cited by:

    1. Lulu Sun & Yi Zhang & Jie Cai & Bipin Rimal & Edson R. Rocha & James P. Coleman & Chenran Zhang & Robert G. Nichols & Yuhong Luo & Bora Kim & Yaozong Chen & Kristopher W. Krausz & Curtis C. Harris & A, 2023. "Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Hao Li & Meng Wang & Biao Huang & Su-Wen Zhu & Jun-Jie Zhou & De-Run Chen & Ran Cui & Mingxi Zhang & Zhi-Jun Sun, 2021. "Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Juntao Chen & Cuidi Xu & Kun Yang & Rifeng Gao & Yirui Cao & Lifei Liang & Siyue Chen & Shihao Xu & Ruiming Rong & Jina Wang & Tongyu Zhu, 2023. "Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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