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XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast

Author

Listed:
  • E. L. van Dijk

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • C. L. Chen

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • Y. d’Aubenton-Carafa

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • S. Gourvennec

    (ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • M. Kwapisz

    (ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • V. Roche

    (ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • C. Bertrand

    (ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • M. Silvain

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • P. Legoix-Né

    (NGS Platform, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • S. Loeillet

    (Recombination and Genome instability, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • A. Nicolas

    (Recombination and Genome instability, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • C. Thermes

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France)

  • A. Morillon

    (Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
    ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

Abstract

Antisense control by ncRNAs Several lines of evidence suggest that non-coding RNAs (ncRNAs) have a significant role in gene regulation in eukaryotes. Genome-wide deep sequencing in the yeast Saccharomyces cerevisiae has now identified antisense ncRNAs that are destabilized by the Xrn1 RNA exonuclease in the 5′ RNA-decay pathway. These Xrn1-sensitive unstable transcripts, or XUTs, seem to function in gene repression and can be antagonized by histone H3K4 trimethylation.

Suggested Citation

  • E. L. van Dijk & C. L. Chen & Y. d’Aubenton-Carafa & S. Gourvennec & M. Kwapisz & V. Roche & C. Bertrand & M. Silvain & P. Legoix-Né & S. Loeillet & A. Nicolas & C. Thermes & A. Morillon, 2011. "XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast," Nature, Nature, vol. 475(7354), pages 114-117, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7354:d:10.1038_nature10118
    DOI: 10.1038/nature10118
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    Cited by:

    1. Chun Zhou & Yun Wang & Yikun Huang & Yongpan An & Xian Fu & Daqian Yang & Yilin Wang & Jintao Zhang & Leslie A. Mitchell & Joel S. Bader & Yizhi Cai & Junbiao Dai & Jef D. Boeke & Zhiming Cai & Zhengw, 2024. "The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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