IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v474y2011i7353d10.1038_nature10195.html
   My bibliography  Save this article

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Author

Listed:
  • Kasia Hrecka

    (Case School of Medicine
    Cold Spring Harbor Laboratory)

  • Caili Hao

    (Case School of Medicine)

  • Magda Gierszewska

    (Cold Spring Harbor Laboratory)

  • Selene K. Swanson

    (Stowers Institute for Medical Research)

  • Malgorzata Kesik-Brodacka

    (Case School of Medicine
    Present addresses: Department of Pathology, New York School of Medicine, New York, New York 10016, USA (S.S.); Institute of Biotechnology and Antibiotics, Warsaw 02-516, Poland (M.K.-B.).)

  • Smita Srivastava

    (Cold Spring Harbor Laboratory
    Present addresses: Department of Pathology, New York School of Medicine, New York, New York 10016, USA (S.S.); Institute of Biotechnology and Antibiotics, Warsaw 02-516, Poland (M.K.-B.).)

  • Laurence Florens

    (Stowers Institute for Medical Research)

  • Michael P. Washburn

    (Stowers Institute for Medical Research
    University of Kansas Medical Center)

  • Jacek Skowronski

    (Case School of Medicine
    Cold Spring Harbor Laboratory)

Abstract

How macrophages avoid HIV-1 infection HIV-1 is unable to replicate efficiently in dendritic cells, the antigen-presenting tissue cells that function in both innate and adaptive immunity. Other primate lentiviruses, including HIV-2 and some simian immunodeficiency viruses, express a protein called Vpx that is able to overcome the block to replication. Two groups now report the identification of the restriction factor in dendritic cells and macrophages that is overcome by Vpx. Vpx is found to induce degradation of the protein SAMHD1. Mutations in SAMHD1 cause Aicardi–Goutières syndrome, a disorder characterized by inappropriate activation of the immune system. Knockdown of SAMHD1 increases HIV-1 replication in dendritic cells, which could be important for generating appropriate immune responses to the virus.

Suggested Citation

  • Kasia Hrecka & Caili Hao & Magda Gierszewska & Selene K. Swanson & Malgorzata Kesik-Brodacka & Smita Srivastava & Laurence Florens & Michael P. Washburn & Jacek Skowronski, 2011. "Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein," Nature, Nature, vol. 474(7353), pages 658-661, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10195
    DOI: 10.1038/nature10195
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10195
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10195?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Priya Kapoor-Vazirani & Sandip K. Rath & Xu Liu & Zhen Shu & Nicole E. Bowen & Yitong Chen & Ramona Haji-Seyed-Javadi & Waaqo Daddacha & Elizabeth V. Minten & Diana Danelia & Daniela Farchi & Duc M. D, 2022. "SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Lisa D. J. Schiffelers & Yonas M. Tesfamariam & Lea-Marie Jenster & Stefan Diehl & Sophie C. Binder & Sabine Normann & Jonathan Mayr & Steffen Pritzl & Elena Hagelauer & Anja Kopp & Assaf Alon & Matth, 2024. "Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Oliver J. Acton & Devon Sheppard & Simone Kunzelmann & Sarah J. Caswell & Andrea Nans & Ailidh J. O. Burgess & Geoff Kelly & Elizabeth R. Morris & Peter B. Rosenthal & Ian A. Taylor, 2024. "Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10195. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.