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Latent TGF-β binding protein 3 identifies a second heart field in zebrafish

Author

Listed:
  • Yong Zhou

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Timothy J. Cashman

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Kathleen R. Nevis

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Pablo Obregon

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Sara A. Carney

    (School of Pharmacy, University of Wisconsin)

  • Yan Liu

    (Harvard Medical School, Boston, Massachusetts 02115, USA
    Massachusetts General Hospital)

  • Aihua Gu

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA
    School of Public Health, Nanjing Medical University)

  • Christian Mosimann

    (Harvard Medical School, Boston, Massachusetts 02115, USA
    Children’s Hospital Boston)

  • Samuel Sondalle

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Harvard Stem Cell Institute)

  • Richard E. Peterson

    (School of Pharmacy, University of Wisconsin)

  • Warren Heideman

    (School of Pharmacy, University of Wisconsin)

  • Caroline E. Burns

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Harvard Stem Cell Institute)

  • C. Geoffrey Burns

    (Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Affairs of the embryonic heart Progenitor cells from the second heart field, which generate the right ventricle, were considered unique to higher vertebrates with four-chambered hearts. Researchers have now identified a group of cardiac progenitors that express the TGF-β signalling regulator ltbp3 that contributes late-differentiating myocytes to the ventricle and outflow tract of zebrafish. This suggests that lower vertebrates also have second-heart-field cells, which augment the function of the single ventricular chamber. The trait may have conferred an evolutionary advantage to a common ancestor of zebrafish and mammals.

Suggested Citation

  • Yong Zhou & Timothy J. Cashman & Kathleen R. Nevis & Pablo Obregon & Sara A. Carney & Yan Liu & Aihua Gu & Christian Mosimann & Samuel Sondalle & Richard E. Peterson & Warren Heideman & Caroline E. Bu, 2011. "Latent TGF-β binding protein 3 identifies a second heart field in zebrafish," Nature, Nature, vol. 474(7353), pages 645-648, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10094
    DOI: 10.1038/nature10094
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    Cited by:

    1. Jacob T. Gafranek & Enrico D’Aniello & Padmapriyadarshini Ravisankar & Kairavee Thakkar & Ronald J. Vagnozzi & Hee-Woong Lim & Nathan Salomonis & Joshua S. Waxman, 2023. "Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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