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A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

Author

Listed:
  • Jae Man Lee

    (Program in Developmental Biology, Baylor College of Medicine)

  • Yoon Kwang Lee

    (Baylor College of Medicine
    Northeastern Ohio Universities Colleges of Medicine and Pharmacy)

  • Jennifer L. Mamrosh

    (Baylor College of Medicine)

  • Scott A. Busby

    (The Scripps Research Molecular Screening Center, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA)

  • Patrick R. Griffin

    (The Scripps Research Molecular Screening Center, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA)

  • Manish C. Pathak

    (Emory University School of Medicine)

  • Eric A. Ortlund

    (Emory University School of Medicine)

  • David D. Moore

    (Program in Developmental Biology, Baylor College of Medicine
    Baylor College of Medicine)

Abstract

An antidiabetic LRH-1 agonist Excess liver fat, or steatosis, is an important risk factor for obesity-associated diabetes. A natural product, dilauroyl phosphatidylcholine (DLPC), has now been identified as a possible antisteatosis agent, with therapeutic potential in pre-diabetic people. DLPC activates the orphan nuclear receptor LRH-1, loss of which decreases bile acid levels. Elevated bile acid is known to decrease steatosis. Acting as an LHR-1 agonist, DLPC decreases hepatic steatosis and improves glucose homeostasis in mouse models of insulin resistance.

Suggested Citation

  • Jae Man Lee & Yoon Kwang Lee & Jennifer L. Mamrosh & Scott A. Busby & Patrick R. Griffin & Manish C. Pathak & Eric A. Ortlund & David D. Moore, 2011. "A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects," Nature, Nature, vol. 474(7352), pages 506-510, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature10111
    DOI: 10.1038/nature10111
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    Cited by:

    1. Xiaodi Hu & Mingwei Sun & Qian Chen & Yixia Zhao & Na Liang & Siyuan Wang & Pengbin Yin & Yuanping Yang & Sin Man Lam & Qianying Zhang & Alimujiang Tudiyusufu & Yingying Gu & Xin Wan & Meihong Chen & , 2023. "Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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