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Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors

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  • Gisela D. Cymes

    (Center for Biophysics and Computational Biology, and Neuroscience Program, University of Illinois at Urbana-Champaign)

  • Claudio Grosman

    (Center for Biophysics and Computational Biology, and Neuroscience Program, University of Illinois at Urbana-Champaign)

Abstract

A versatile receptor family The nicotinic-receptor superfamily is the only family of ion channels that has evolved to generate both cation- and anion-selective members. The underlying mechanism for the observed charge selectivity is not entirely clear. Gisela Cymes and Claudio Grosman have determined that anion-selective type sequences favour the protonation of a conserved, basic amino acid residue at the intracellular entrance of the pore channel, whereas cation-selective type sequences prevent this protonation. This suggests that the charge state of buried basic amino acid side chains is an essential feature of the charge-selectivity filter of this family of ion channels.

Suggested Citation

  • Gisela D. Cymes & Claudio Grosman, 2011. "Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors," Nature, Nature, vol. 474(7352), pages 526-530, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature10015
    DOI: 10.1038/nature10015
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    Cited by:

    1. Grigory Maksaev & Michael Bründl-Jirout & Anna Stary-Weinzinger & Eva-Maria Zangerl-Plessl & Sun-Joo Lee & Colin G. Nichols, 2023. "Subunit gating resulting from individual protonation events in Kir2 channels," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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