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Determinants of nucleosome organization in primary human cells

Author

Listed:
  • Anton Valouev

    (Stanford University School of Medicine, 300 Pasteur Drive)

  • Steven M. Johnson

    (Brigham Young University, 757 WIDB)

  • Scott D. Boyd

    (Stanford University School of Medicine, 300 Pasteur Drive)

  • Cheryl L. Smith

    (Stanford University School of Medicine, 300 Pasteur Drive)

  • Andrew Z. Fire

    (Stanford University School of Medicine, 300 Pasteur Drive
    Stanford University School of Medicine, Pasteur Drive)

  • Arend Sidow

    (Stanford University School of Medicine, 300 Pasteur Drive
    Stanford University School of Medicine, Pasteur Drive)

Abstract

Nucleosome positions mapped The organization of nucleosomes across the genome influences gene regulation, and understanding the mechanisms that underlie this organization in different organisms is an active area of research. In this study, genome-wide maps of nucleosome positions in three primary human cell types and in vitro have been generated by high-throughput DNA sequencing. Most of the genome exhibits substantial flexibility of nucleosome positions, and a combination of intrinsic sequence-based nucleosome preferences and interactions with non-nucleosomal factors determine nucleosome organization in vivo.

Suggested Citation

  • Anton Valouev & Steven M. Johnson & Scott D. Boyd & Cheryl L. Smith & Andrew Z. Fire & Arend Sidow, 2011. "Determinants of nucleosome organization in primary human cells," Nature, Nature, vol. 474(7352), pages 516-520, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature10002
    DOI: 10.1038/nature10002
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    Cited by:

    1. Rina Hirano & Haruhiko Ehara & Tomoya Kujirai & Tamami Uejima & Yoshimasa Takizawa & Shun-ichi Sekine & Hitoshi Kurumizaka, 2022. "Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Monica Naughtin & Zofia Haftek-Terreau & Johan Xavier & Sam Meyer & Maud Silvain & Yan Jaszczyszyn & Nicolas Levy & Vincent Miele & Mohamed Salah Benleulmi & Marc Ruff & Vincent Parissi & Cédric Vaill, 2015. "DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-28, June.
    3. Tianbao Li & Qi Liu & Zhong Chen & Kun Fang & Furong Huang & Xueqi Fu & Qianben Wang & Victor X. Jin, 2022. "Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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