IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v474y2011i7352d10.1038_nature09992.html
   My bibliography  Save this article

Non-adaptive origins of interactome complexity

Author

Listed:
  • Ariel Fernández

    (The University of Chicago
    Rice University)

  • Michael Lynch

    (Indiana University)

Abstract

How proteins get the drift Sampling bias in small populations can result in a non-adaptive evolutionary phenomenon called genetic drift. By comparing the protein-coding genomes of many species, Ariel Fernández and Michael Lynch show that population-size bottlenecks allow for the appearance of mildly destabilized proteins that can subsequently be re-stabilized through new protein–protein interactions. These interactions can then evolve into meaningful biochemical pathways. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge through non-adaptive mechanisms.

Suggested Citation

  • Ariel Fernández & Michael Lynch, 2011. "Non-adaptive origins of interactome complexity," Nature, Nature, vol. 474(7352), pages 502-505, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature09992
    DOI: 10.1038/nature09992
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09992
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09992?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhaoxiang He & Mengchen Wu & Hongtao Tian & Liangdong Wang & Yiqi Hu & Fangzhu Han & Jiancang Zhou & Yong Wang & Long Zhou, 2024. "Euglena’s atypical respiratory chain adapts to the discoidal cristae and flexible metabolism," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature09992. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.