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Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

Author

Listed:
  • Dong Wang

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Ivan Garcia-Bassets

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Chris Benner

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Wenbo Li

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Xue Su

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Graduate Program in Biology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Yiming Zhou

    (Digomics LLC, PO Box 30, Malden, Massachusetts 02148, USA)

  • Jinsong Qiu

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Wen Liu

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Graduate Program in Biology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Minna U. Kaikkonen

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Kenneth A. Ohgi

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Christopher K. Glass

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Xiang-Dong Fu

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

Abstract

FoxA genomic surveillance mechanism Transcriptional enhancers orchestrate cell-type-specific gene expression programs, but how they convey signal-activated transcriptional responses remains poorly understood. Here, the cell-lineage-specific transcription factor FoxA1 is shown to both facilitate and restrict the androgen receptor to act on distinct classes of enhancers. Lowered levels of FoxA1, such as those found in prostate cancer, can reprogram the hormonal response by causing a switch in androgen receptor binding to a set of pre-established, functional enhancers that are marked by enhancer-derived non-coding RNAs (eRNAs). This work points to the existence of a large repository of active enhancers that can be tuned to allow alternative gene expression programs in normal cell development and in disease progression.

Suggested Citation

  • Dong Wang & Ivan Garcia-Bassets & Chris Benner & Wenbo Li & Xue Su & Yiming Zhou & Jinsong Qiu & Wen Liu & Minna U. Kaikkonen & Kenneth A. Ohgi & Christopher K. Glass & Michael G. Rosenfeld & Xiang-Do, 2011. "Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA," Nature, Nature, vol. 474(7351), pages 390-394, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10006
    DOI: 10.1038/nature10006
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    Cited by:

    1. Kunkun Zhang & Shaoxuan Chen & Qihua Yang & Shuanghui Guo & Qiang Chen & Zhixiong Liu & Li Li & Mengyun Jiang & Hongda Li & Jin Hu & Xu Pan & Wenbo Deng & Naian Xiao & Bo Wang & Zhan-xiang Wang & Lian, 2022. "The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Michael G Heckman & Jessica L Robinson & Katherine S Tzou & Alexander S Parker & Kevin J Wu & Tracy W Hilton & William J Howat & Jodi L Miller & Pamela A Kreinest & Thomas M Pisansky & Steven E Schild, 2016. "An Examination of the Association between FOXA1 Staining Level and Biochemical Recurrence following Salvage Radiation Therapy for Recurrent Prostate Cancer," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.

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