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COP1 is a tumour suppressor that causes degradation of ETS transcription factors

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  • Alberto C. Vitari

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
    Present addresses: Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608, USA (A.C.V.); Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China (W.-Q.G.).)

  • Kevin G. Leong

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Kim Newton

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Cindy Yee

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Karen O’Rourke

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jinfeng Liu

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Lilian Phu

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Rajesh Vij

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ronald Ferrando

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Suzana S. Couto

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Sankar Mohan

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ajay Pandita

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jo-Anne Hongo

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • David Arnott

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ingrid E. Wertz

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Wei-Qiang Gao

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
    Present addresses: Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608, USA (A.C.V.); Renji-MedX Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China (W.-Q.G.).)

  • Dorothy M. French

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Vishva M. Dixit

    (Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

COP1 in prostate cancer Translocations in transcription factors in the E26 transformation-specific (ETS) family are common in prostate cancer. Dixit and colleagues now find that the ubiquitin ligase COP1 normally ubiquitinates certain ETS factors, leading to their degradation. The proteins encoded by the translocations, however, lack the COP1 signal and thus evade degradation. COP1 acts as a tumour suppressor, and its deletion causes neoplasias in the mouse prostate by increasing ETS factor levels. The authors also show that the loss of COP1, like ETS translocations, can lead to upregulation of ETS factors in human prostate cancers.

Suggested Citation

  • Alberto C. Vitari & Kevin G. Leong & Kim Newton & Cindy Yee & Karen O’Rourke & Jinfeng Liu & Lilian Phu & Rajesh Vij & Ronald Ferrando & Suzana S. Couto & Sankar Mohan & Ajay Pandita & Jo-Anne Hongo &, 2011. "COP1 is a tumour suppressor that causes degradation of ETS transcription factors," Nature, Nature, vol. 474(7351), pages 403-406, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10005
    DOI: 10.1038/nature10005
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    Cited by:

    1. Jing Liu & Collin Tokheim & Jonathan D. Lee & Wenjian Gan & Brian J. North & X. Shirley Liu & Pier Paolo Pandolfi & Wenyi Wei, 2021. "Genetic fusions favor tumorigenesis through degron loss in oncogenes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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