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A genetically humanized mouse model for hepatitis C virus infection

Author

Listed:
  • Marcus Dorner

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Joshua A. Horwitz

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Justin B. Robbins

    (The Scripps Research Institute)

  • Walter T. Barry

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Qian Feng

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Kathy Mu

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Christopher T. Jones

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • John W. Schoggins

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Maria Teresa Catanese

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Dennis R. Burton

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Ragon Institute of MGH, MIT and Harvard)

  • Mansun Law

    (The Scripps Research Institute)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Alexander Ploss

    (Center for the Study of Hepatitis C, The Rockefeller University)

Abstract

A mouse model for hepatitis C infection The development of therapies for hepatitis C virus (HCV) infection has been hampered by the lack of a small-animal model of the disease. Now Alexander Ploss and colleagues describe the first immunocompetent rodent model for hepatitis C virus infection, using adenoviruses expressing four human factors to enable entry of HCV into mouse cells. These vectors were then used to transduce the livers of mice, which then became susceptible to HCV infection. Although the model does not enable a complete virus replication cycle, it should be useful for the evaluation of HCV vaccines and entry inhibitors.

Suggested Citation

  • Marcus Dorner & Joshua A. Horwitz & Justin B. Robbins & Walter T. Barry & Qian Feng & Kathy Mu & Christopher T. Jones & John W. Schoggins & Maria Teresa Catanese & Dennis R. Burton & Mansun Law & Char, 2011. "A genetically humanized mouse model for hepatitis C virus infection," Nature, Nature, vol. 474(7350), pages 208-211, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7350:d:10.1038_nature10168
    DOI: 10.1038/nature10168
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    Cited by:

    1. Pranesh Padmanabhan & Narendra M Dixit, 2011. "Mathematical Model of Viral Kinetics In Vitro Estimates the Number of E2-CD81 Complexes Necessary for Hepatitis C Virus Entry," PLOS Computational Biology, Public Library of Science, vol. 7(12), pages 1-11, December.

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