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In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

Author

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  • Joji Fujisaki

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street)

  • Juwell Wu

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street
    77 Massachusetts Avenue, E25-519, Cambridge, Massachusetts 02139, USA)

  • Alicia L. Carlson

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Lev Silberstein

    (Harvard Stem Cell Institute, 42 Church Street
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Prabhakar Putheti

    (Beth Israel Deaconess Medical Center)

  • Rafael Larocca

    (Beth Israel Deaconess Medical Center)

  • Wenda Gao

    (Beth Israel Deaconess Medical Center)

  • Toshiki I. Saito

    (Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg.149-5102 13th Street, Boston, Massachusetts 02129, USA
    Present addresses: Department of Regenerative Medicine, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya Aichi 460-0001, Japan (T.I.S.); Columbia Center for Translational Immunology, Columbia University Medical Center, 650 W. 168th Street, BB 1512, New York, New York 10032, USA (M.S.).)

  • Cristina Lo Celso

    (Harvard Stem Cell Institute, 42 Church Street
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Hitoshi Tsuyuzaki

    (Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Tatsuyuki Sato

    (Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Daniel Côté

    (Génie Physique et Optique & Centre de Recherche Université Laval Robert-Giffard, Québec City, Québec G1J 2G3, Canada)

  • Megan Sykes

    (Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, MGH-East, Bldg.149-5102 13th Street, Boston, Massachusetts 02129, USA
    Present addresses: Department of Regenerative Medicine, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya Aichi 460-0001, Japan (T.I.S.); Columbia Center for Translational Immunology, Columbia University Medical Center, 650 W. 168th Street, BB 1512, New York, New York 10032, USA (M.S.).)

  • Terry B. Strom

    (Beth Israel Deaconess Medical Center)

  • David T. Scadden

    (Harvard Stem Cell Institute, 42 Church Street
    Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Charles P. Lin

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, CPZN 8238, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street)

Abstract

A privileged position A new study identifies the bone marrow haematopoietic stem cell (HSC) niche — a specialized microenvironment where stem cells reside — as an immune privileged site. This property is known to exist in the testis, ovary and hair follicle but has not been universally demonstrated in all stem cell niches. High-resolution in vivo imaging shows the accumulation of regulatory T cells in the HSC niche, enabling transplanted allo-HSCs to escape from allogeneic rejection. As well as supporting stem-cell function, the niche may provide a relative sanctuary from immune attack that could extend to malignant cells in some instances.

Suggested Citation

  • Joji Fujisaki & Juwell Wu & Alicia L. Carlson & Lev Silberstein & Prabhakar Putheti & Rafael Larocca & Wenda Gao & Toshiki I. Saito & Cristina Lo Celso & Hitoshi Tsuyuzaki & Tatsuyuki Sato & Daniel Cô, 2011. "In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche," Nature, Nature, vol. 474(7350), pages 216-219, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7350:d:10.1038_nature10160
    DOI: 10.1038/nature10160
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    Cited by:

    1. Jacqueline Feyen & Zhen Ping & Lanpeng Chen & Claire Dijk & Tim V. D. Tienhoven & Paulina M. H. Strien & Remco M. Hoogenboezem & Michiel J. W. Wevers & Mathijs A. Sanders & Ivo P. Touw & Marc H. G. P., 2022. "Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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