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Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

Author

Listed:
  • Scott G. Hansen

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Julia C. Ford

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Matthew S. Lewis

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Abigail B. Ventura

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Colette M. Hughes

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Lia Coyne-Johnson

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Nathan Whizin

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Kelli Oswald

    (AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick)

  • Rebecca Shoemaker

    (AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick)

  • Tonya Swanson

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Alfred W. Legasse

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Maria J. Chiuchiolo

    (International AIDS Vaccine Initiative, Vaccine Design and Development Laboratory, 140 58th Street, Building A, Unit 8J, Brooklyn, New York 11220, USA)

  • Christopher L. Parks

    (International AIDS Vaccine Initiative, Vaccine Design and Development Laboratory, 140 58th Street, Building A, Unit 8J, Brooklyn, New York 11220, USA)

  • Michael K. Axthelm

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Jay A. Nelson

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Michael A. Jarvis

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

  • Michael Piatak

    (AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, SAIC Frederick Inc., National Cancer Institute-Frederick)

  • Louis J. Picker

    (Vaccine and Gene Therapy Institute, and the Oregon National Primate Research Center, Oregon Health & Science University)

Abstract

Towards T-cell vaccines for HIV/AIDS Following some high-profile clinical trial failures in recent years, the emphasis in HIV/AIDS vaccine research has shifted away from T-cell-based vaccines that control viral replication towards vaccines that block acquisition of infection. Hansen et al. take a novel route to T-cell-based immunity, using cytomegalovirus (CMV) vectors. They find that vaccination with a rhesus-CMV-based vaccine against simian immunodeficiency virus (SIV) provides long-term protection from SIV challenge in rhesus macaques. Protection seems to be mediated by tissue-resident T-effector memory responses, suggesting that persistent vectors such as CMV may be effective in HIV/AIDS vaccines.

Suggested Citation

  • Scott G. Hansen & Julia C. Ford & Matthew S. Lewis & Abigail B. Ventura & Colette M. Hughes & Lia Coyne-Johnson & Nathan Whizin & Kelli Oswald & Rebecca Shoemaker & Tonya Swanson & Alfred W. Legasse &, 2011. "Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine," Nature, Nature, vol. 473(7348), pages 523-527, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7348:d:10.1038_nature10003
    DOI: 10.1038/nature10003
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    Cited by:

    1. Fangzhu Zhao & Zachary T. Berndsen & Nuria Pedreño-Lopez & Alison Burns & Joel D. Allen & Shawn Barman & Wen-Hsin Lee & Srirupa Chakraborty & Sandrasegaram Gnanakaran & Leigh M. Sewall & Gabriel Ozoro, 2022. "Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Daniel Malouli & Meenakshi Tiwary & Roxanne M. Gilbride & David W. Morrow & Colette M. Hughes & Andrea Selseth & Toni Penney & Priscila Castanha & Megan Wallace & Yulia Yeung & Morgan Midgett & Connor, 2024. "Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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