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Neural crest regulates myogenesis through the transient activation of NOTCH

Author

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  • Anne C. Rios

    (EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
    Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia)

  • Olivier Serralbo

    (EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
    Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia)

  • David Salgado

    (EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
    Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia)

  • Christophe Marcelle

    (EMBL Australia; Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia
    Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia)

Abstract

A role for NOTCH in muscle development During the first days of embryonic development, somites contain stem and progenitor epithelial cells that either self-renew or undergo myogenesis. Secreted factors from surrounding tissues either activate or inhibit myogenesis in somites, but why do only a few cells at a time undergo myogenic differentiation if all cells within somites are exposed to these factors? Rios et al. show that cell fate choice in the somites is dependent on whether progenitor cells experience a transient activation of NOTCH signalling, and that this transient signal is triggered by migrating neural crest cells en route to their sites of differentiation.

Suggested Citation

  • Anne C. Rios & Olivier Serralbo & David Salgado & Christophe Marcelle, 2011. "Neural crest regulates myogenesis through the transient activation of NOTCH," Nature, Nature, vol. 473(7348), pages 532-535, May.
  • Handle: RePEc:nat:nature:v:473:y:2011:i:7348:d:10.1038_nature09970
    DOI: 10.1038/nature09970
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    Cited by:

    1. Thomas Daniele & Jeanne Cury & Marie-Charlotte Morin & Arnaud Ahier & Davide Isaia & Sophie Jarriault, 2025. "Essential and dual effects of Notch activity on a natural transdifferentiation event," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

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