IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v473y2011i7347d10.1038_nature10008.html
   My bibliography  Save this article

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Author

Listed:
  • Gabriella Ficz

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • Miguel R. Branco

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • Stefanie Seisenberger

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • Fátima Santos

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • Felix Krueger

    (Bioinformatics Group, The Babraham Institute)

  • Timothy A. Hore

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute)

  • C. Joana Marques

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
    Present address: Genetics Department, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.)

  • Simon Andrews

    (Bioinformatics Group, The Babraham Institute)

  • Wolf Reik

    (Laboratory of Developmental Genetics and Imprinting, The Babraham Institute
    Centre for Trophoblast Research, University of Cambridge)

Abstract

Fine-tuning DNA methylation by Tet proteins The modified DNA base 5-hydroxymethylcytosine (5hmC), sometimes called the sixth base, is present in the mammalian genome where it is generated by oxidation of 5-methylcytosine (5mC; the fifth base) by enzymes of the Tet family. Four papers in this issue, from the Helin, Zhang, Rao and Reik laboratories, respectively, report on the genome-wide distribution of Tet1 and/or 5hmC in mouse embryonic stem cells using the ChIP-seq technique. Links between Tet1 and transcription regulation — both activation and repression — are revealed. Anjana Rao and colleagues also describe two alternative methods with increased sensitivity for mapping single 5hmC bases. In the associated News & Views, Nathalie Véron and Antoine H. F. M. Peters discuss what these and other recent papers reveal about the role of Tet proteins in regulating DNA methylation and gene expression.

Suggested Citation

  • Gabriella Ficz & Miguel R. Branco & Stefanie Seisenberger & Fátima Santos & Felix Krueger & Timothy A. Hore & C. Joana Marques & Simon Andrews & Wolf Reik, 2011. "Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation," Nature, Nature, vol. 473(7347), pages 398-402, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature10008
    DOI: 10.1038/nature10008
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10008
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10008?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xu Hua & Hui Zhou & Hui-Chen Wu & Julia Furnari & Corina P. Kotidis & Raul Rabadan & Jeanine M. Genkinger & Jeffrey N. Bruce & Peter Canoll & Regina M. Santella & Zhiguo Zhang, 2024. "Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature10008. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.