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Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

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  • Helen S. Goodridge

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
    Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard
    David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, University of California)

  • Christopher N. Reyes

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)

  • Courtney A. Becker

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)

  • Tamiko R. Katsumoto

    (Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California)

  • Jun Ma

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)

  • Andrea J. Wolf

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)

  • Nandita Bose

    (Biothera, 3388 Mike Collins Drive)

  • Anissa S. H. Chan

    (Biothera, 3388 Mike Collins Drive)

  • Andrew S. Magee

    (Biothera, 3388 Mike Collins Drive)

  • Michael E. Danielson

    (Biothera, 3388 Mike Collins Drive)

  • Arthur Weiss

    (Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California
    Howard Hughes Medical Institute, University of California)

  • John P. Vasilakos

    (Biothera, 3388 Mike Collins Drive)

  • David M. Underhill

    (IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
    David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, University of California)

Abstract

How the innate immune system spots fungal pathogens Invading microbes are detected and ingested by white blood cells known as phagocytes. To do this they must distinguish between soluble microbe-derived components, such as pieces of cell wall, and the particulate microbes themselves. A study of the action of Dectin-1, an innate immune receptor that detects invading fungal pathogens, shows that although the receptor binds to both soluble and particulate cell-wall β-glucans, its activation is restricted to sites of contact with fungal cell walls by the formation of 'phagocytic synapses'. The phagocytic synapse provides a mechanistic model for the specific detection of ligands associated with a microbial surface, as opposed to those released from microbes at a distance.

Suggested Citation

  • Helen S. Goodridge & Christopher N. Reyes & Courtney A. Becker & Tamiko R. Katsumoto & Jun Ma & Andrea J. Wolf & Nandita Bose & Anissa S. H. Chan & Andrew S. Magee & Michael E. Danielson & Arthur Weis, 2011. "Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’," Nature, Nature, vol. 472(7344), pages 471-475, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature10071
    DOI: 10.1038/nature10071
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    Cited by:

    1. Anne E. Geller & Rejeena Shrestha & Matthew R. Woeste & Haixun Guo & Xiaoling Hu & Chuanlin Ding & Kalina Andreeva & Julia H. Chariker & Mingqian Zhou & David Tieri & Corey T. Watson & Robert A. Mitch, 2022. "The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Han Gao & Sen Li & Zhengyi Lan & Da Pan & Gonna Somu Naidu & Dan Peer & Chenyi Ye & Hangrong Chen & Ming Ma & Zehua Liu & Hélder A. Santos, 2024. "Comparative optimization of polysaccharide-based nanoformulations for cardiac RNAi therapy," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Torben Mentrup & Anna Yamina Stumpff-Niggemann & Nadja Leinung & Christine Schlosser & Katja Schubert & Rebekka Wehner & Antje Tunger & Valentin Schatz & Patrick Neubert & Ann-Christine Gradtke & Jani, 2022. "Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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