Author
Listed:
- Helen S. Goodridge
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard
David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, University of California)
- Christopher N. Reyes
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)
- Courtney A. Becker
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)
- Tamiko R. Katsumoto
(Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California)
- Jun Ma
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)
- Andrea J. Wolf
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center)
- Nandita Bose
(Biothera, 3388 Mike Collins Drive)
- Anissa S. H. Chan
(Biothera, 3388 Mike Collins Drive)
- Andrew S. Magee
(Biothera, 3388 Mike Collins Drive)
- Michael E. Danielson
(Biothera, 3388 Mike Collins Drive)
- Arthur Weiss
(Rosalind Russell Medical Research Center for Arthritis, 513 Parnassus, University of California
Howard Hughes Medical Institute, University of California)
- John P. Vasilakos
(Biothera, 3388 Mike Collins Drive)
- David M. Underhill
(IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars-Sinai Medical Center
David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, University of California)
Abstract
How the innate immune system spots fungal pathogens Invading microbes are detected and ingested by white blood cells known as phagocytes. To do this they must distinguish between soluble microbe-derived components, such as pieces of cell wall, and the particulate microbes themselves. A study of the action of Dectin-1, an innate immune receptor that detects invading fungal pathogens, shows that although the receptor binds to both soluble and particulate cell-wall β-glucans, its activation is restricted to sites of contact with fungal cell walls by the formation of 'phagocytic synapses'. The phagocytic synapse provides a mechanistic model for the specific detection of ligands associated with a microbial surface, as opposed to those released from microbes at a distance.
Suggested Citation
Helen S. Goodridge & Christopher N. Reyes & Courtney A. Becker & Tamiko R. Katsumoto & Jun Ma & Andrea J. Wolf & Nandita Bose & Anissa S. H. Chan & Andrew S. Magee & Michael E. Danielson & Arthur Weis, 2011.
"Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’,"
Nature, Nature, vol. 472(7344), pages 471-475, April.
Handle:
RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature10071
DOI: 10.1038/nature10071
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Citations
Citations are extracted by the
CitEc Project, subscribe to its
RSS feed for this item.
Cited by:
- Anne E. Geller & Rejeena Shrestha & Matthew R. Woeste & Haixun Guo & Xiaoling Hu & Chuanlin Ding & Kalina Andreeva & Julia H. Chariker & Mingqian Zhou & David Tieri & Corey T. Watson & Robert A. Mitch, 2022.
"The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression,"
Nature Communications, Nature, vol. 13(1), pages 1-20, December.
- Torben Mentrup & Anna Yamina Stumpff-Niggemann & Nadja Leinung & Christine Schlosser & Katja Schubert & Rebekka Wehner & Antje Tunger & Valentin Schatz & Patrick Neubert & Ann-Christine Gradtke & Jani, 2022.
"Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis,"
Nature Communications, Nature, vol. 13(1), pages 1-18, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature10071. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.