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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

Author

Listed:
  • A. Phillip West

    (Yale University School of Medicine)

  • Igor E. Brodsky

    (Yale University School of Medicine
    Present address: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA.)

  • Christoph Rahner

    (Yale University School of Medicine)

  • Dong Kyun Woo

    (Yale University School of Medicine)

  • Hediye Erdjument-Bromage

    (Molecular Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Paul Tempst

    (Molecular Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Matthew C. Walsh

    (University of Pennsylvania School of Medicine)

  • Yongwon Choi

    (University of Pennsylvania School of Medicine)

  • Gerald S. Shadel

    (Yale University School of Medicine)

  • Sankar Ghosh

    (College of Physicians and Surgeons, Columbia University)

Abstract

Mitochondrial role in innate immunity The stimulation of a subset of surface Toll-like receptors (TLRs), transmembrane proteins of the innate immune system that recognize microbe-derived molecules, is shown to induce production of reactive oxygen for bacterial killing by the mitochondrial pathway. When the 'bacterial' TLRs (TLR1, 2 and 4) bind to a ligand they promote the recruitment of mitochondria to macrophage phagosomes and induce upregulation of mitochondrial reactive oxygen species (mROS). This work implicates mROS as important components of antibacterial responses and further establishes mitochondria as hubs for innate immune signalling.

Suggested Citation

  • A. Phillip West & Igor E. Brodsky & Christoph Rahner & Dong Kyun Woo & Hediye Erdjument-Bromage & Paul Tempst & Matthew C. Walsh & Yongwon Choi & Gerald S. Shadel & Sankar Ghosh, 2011. "TLR signalling augments macrophage bactericidal activity through mitochondrial ROS," Nature, Nature, vol. 472(7344), pages 476-480, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature09973
    DOI: 10.1038/nature09973
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    Cited by:

    1. Xudong Wang & Siyu Su & Yuqing Zhu & Xiaolong Cheng & Chen Cheng & Leilei Chen & Anhua Lei & Li Zhang & Yuyan Xu & Dan Ye & Yi Zhang & Wei Li & Jin Zhang, 2023. "Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Lindsay McGregor & Samira Acajjaoui & Ambroise Desfosses & Melissa Saïdi & Maria Bacia-Verloop & Jennifer J. Schwarz & Pauline Juyoux & Jill Velsen & Matthew W. Bowler & Andrew A. McCarthy & Eaazhisai, 2023. "The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jawaher Alharthi & Ali Bayoumi & Khaled Thabet & Ziyan Pan & Brian S. Gloss & Olivier Latchoumanin & Mischa Lundberg & Natalie A. Twine & Duncan McLeod & Shafi Alenizi & Leon A. Adams & Martin Weltman, 2022. "A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Clive Drakeford & Sonia Aguila & Fiona Roche & Karsten Hokamp & Judicael Fazavana & Mariana P. Cervantes & Annie M. Curtis & Heike C. Hawerkamp & Sukhraj Pal Singh Dhami & Hugo Charles-Messance & Emer, 2022. "von Willebrand factor links primary hemostasis to innate immunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Mohammad Naimul Islam & Galina A. Gusarova & Shonit R. Das & Li Li & Eiji Monma & Murari Anjaneyulu & Liberty Mthunzi & Sadiqa K. Quadri & Edward Owusu-Ansah & Sunita Bhattacharya & Jahar Bhattacharya, 2022. "The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Shuai Gao & Lingyu Gao & Dailin Yuan & Xu’ai Lin & Stijn Veen, 2024. "Gonococcal OMV-delivered PorB induces epithelial cell mitophagy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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