IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v472y2011i7343d10.1038_nature09972.html
   My bibliography  Save this article

A transient placental source of serotonin for the fetal forebrain

Author

Listed:
  • Alexandre Bonnin

    (Zilkha Neurogenetic Institute, Keck School of Medicine of USC
    Keck School of Medicine of USC)

  • Nick Goeden

    (Zilkha Neurogenetic Institute, Keck School of Medicine of USC)

  • Kevin Chen

    (USC School of Pharmacy)

  • Melissa L. Wilson

    (Keck School of Medicine of USC)

  • Jennifer King

    (Keck School of Medicine of USC)

  • Jean C. Shih

    (USC School of Pharmacy)

  • Randy D. Blakely

    (Vanderbilt University Medical Center
    Center for Molecular Neuroscience, Vanderbilt University Medical Center)

  • Evan S. Deneris

    (Case Western Reserve University School of Medicine)

  • Pat Levitt

    (Zilkha Neurogenetic Institute, Keck School of Medicine of USC
    Keck School of Medicine of USC)

Abstract

Early sources of serotonin Although it is widely assumed that a maternal contribution to fetal serotonin (5-hydroxytryptamine or 5-HT) levels during pregnancy is important in neurodevelopment, there is little direct experimental evidence to support the idea. Bonnin et al. use new techniques to determine that during early pregnancy the placenta is a significant source of 5-HT, made from maternal tryptophan precursors in both mice and humans. Later in pregnancy, an endogenous 5-HT source in the fetus takes over.

Suggested Citation

  • Alexandre Bonnin & Nick Goeden & Kevin Chen & Melissa L. Wilson & Jennifer King & Jean C. Shih & Randy D. Blakely & Evan S. Deneris & Pat Levitt, 2011. "A transient placental source of serotonin for the fetal forebrain," Nature, Nature, vol. 472(7343), pages 347-350, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09972
    DOI: 10.1038/nature09972
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09972
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09972?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Luca Lambertini & Jia Chen & Yoko Nomura, 2015. "Mitochondrial Gene Expression Profiles Are Associated with Maternal Psychosocial Stress in Pregnancy and Infant Temperament," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-20, September.
    2. Jong Geol Lee & Jung-Min Yon & Globinna Kim & Seul-Gi Lee & C-Yoon Kim & Seung-A Cheong & Hyun-Yi Kim & Jiyoung Yu & Kyunggon Kim & Young Hoon Sung & Hyun Ju Yoo & Dong-Cheol Woo & Jin Kyung Rho & Cha, 2024. "PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09972. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.