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Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration

Author

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  • Aycan Sentürk

    (Frankfurt Institute for Molecular Life Sciences (FMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438)

  • Sylvia Pfennig

    (Frankfurt Institute for Molecular Life Sciences (FMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438)

  • Alexander Weiss

    (Frankfurt Institute for Molecular Life Sciences (FMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438
    Present addresses: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1078, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada (A.W.); IBDML-UMR6216-CNRS, Case 907- Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France (K.B.).)

  • Katja Burk

    (Frankfurt Institute for Molecular Life Sciences (FMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438
    Present addresses: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1078, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada (A.W.); IBDML-UMR6216-CNRS, Case 907- Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France (K.B.).)

  • Amparo Acker-Palmer

    (Frankfurt Institute for Molecular Life Sciences (FMLS) and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438)

Abstract

Reelin in neuronal migration It has long been known that the secreted factor Reelin is crucial for proper neuronal migration during the development of the cortex. However, the mechanistic actions leading to a Reelin response are less well known. Acker-Palmer and colleagues reveal that the axonal guidance cue ephrin B2 acts as a co-factor with Reelin receptors to initiate signalling cascades important to produce the proper lamination of the cortex. This additional role for ephrin B2 expands the functions for this developmental protein beyond proper axonal targeting to cell migration.

Suggested Citation

  • Aycan Sentürk & Sylvia Pfennig & Alexander Weiss & Katja Burk & Amparo Acker-Palmer, 2011. "Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration," Nature, Nature, vol. 472(7343), pages 356-360, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09874
    DOI: 10.1038/nature09874
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    Cited by:

    1. Matan Shelomi, 2014. "Editorial Misconduct—Definition, Cases, and Causes," Publications, MDPI, vol. 2(2), pages 1-10, April.
    2. Tamar Sapir & Aditya Kshirsagar & Anna Gorelik & Tsviya Olender & Ziv Porat & Ingrid E. Scheffer & David B. Goldstein & Orrin Devinsky & Orly Reiner, 2022. "Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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