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Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

Author

Listed:
  • Ikuhiro Okamoto

    (Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934)

  • Catherine Patrat

    (Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934
    Université Paris Diderot – Assistance Publique Hôpitaux de Paris – Service de Biologie de la Reproduction, Hôpital Bichat-Claude Bernard)

  • Dominique Thépot

    (INRA UMR 1198 Biologie du Développement et de la Reproduction)

  • Nathalie Peynot

    (INRA UMR 1198 Biologie du Développement et de la Reproduction)

  • Patricia Fauque

    (Laboratoire de Biologie de la reproduction CECOS, CHU de Dijon, Université de Bourgogne
    Epigenetic Decisions and Reproduction in mammals, Institut Curie, CNRS UMR 3215, INSERM U934)

  • Nathalie Daniel

    (INRA UMR 1198 Biologie du Développement et de la Reproduction)

  • Patricia Diabangouaya

    (Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934)

  • Jean-Philippe Wolf

    (Unité Inserm 1016, Université Paris Descartes – Assistance Publique Hôpitaux de Paris – Service de Biologie de la Reproduction, Hôpital Cochin)

  • Jean-Paul Renard

    (INRA UMR 1198 Biologie du Développement et de la Reproduction)

  • Véronique Duranthon

    (INRA UMR 1198 Biologie du Développement et de la Reproduction)

  • Edith Heard

    (Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934)

Abstract

Mice out of step on X inactivation X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits and humans shows that the processes in mice, in which most of previous analyses have been done, differ significantly from those in other eutherian species. The study highlights a diversity in X-inactivation regulation that may reflect the changing nature of developmental processes during evolution.

Suggested Citation

  • Ikuhiro Okamoto & Catherine Patrat & Dominique Thépot & Nathalie Peynot & Patricia Fauque & Nathalie Daniel & Patricia Diabangouaya & Jean-Philippe Wolf & Jean-Paul Renard & Véronique Duranthon & Edit, 2011. "Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development," Nature, Nature, vol. 472(7343), pages 370-374, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09872
    DOI: 10.1038/nature09872
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    Cited by:

    1. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Jonathan M. Werner & John Hover & Jesse Gillis, 2024. "Population variability in X-chromosome inactivation across 10 mammalian species," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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