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Genome-wide analysis reveals novel molecular features of mouse recombination hotspots

Author

Listed:
  • Fatima Smagulova

    (Uniformed Services University of the Health Sciences)

  • Ivan V. Gregoretti

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH)

  • Kevin Brick

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH)

  • Pavel Khil

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH)

  • R. Daniel Camerini-Otero

    (National Institute of Diabetes, Digestive and Kidney Diseases, NIH)

  • Galina V. Petukhova

    (Uniformed Services University of the Health Sciences)

Abstract

Hot spots for meiotic recombination To initiate the recombination process that guides accurate chromosome segregation during meiosis, programmed double-strand breaks are made at preferred sites known as hot spots. Petukhova and colleagues have now achieved high-resolution genome-wide mapping of meiotic double-strand breaks in mouse cells. The method employed is independent of the availability of genetic markers, a limitation of previous approaches. With these data they have uncovered several features of hot spots at both the sequence and chromatin levels.

Suggested Citation

  • Fatima Smagulova & Ivan V. Gregoretti & Kevin Brick & Pavel Khil & R. Daniel Camerini-Otero & Galina V. Petukhova, 2011. "Genome-wide analysis reveals novel molecular features of mouse recombination hotspots," Nature, Nature, vol. 472(7343), pages 375-378, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7343:d:10.1038_nature09869
    DOI: 10.1038/nature09869
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    Cited by:

    1. Maja Szymanska-Lejman & Wojciech Dziegielewski & Julia Dluzewska & Nadia Kbiri & Anna Bieluszewska & R. Scott Poethig & Piotr A. Ziolkowski, 2023. "The effect of DNA polymorphisms and natural variation on crossover hotspot activity in Arabidopsis hybrids," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Masaru Ito & Asako Furukohri & Kenichiro Matsuzaki & Yurika Fujita & Atsushi Toyoda & Akira Shinohara, 2023. "FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Wu Zuo & Guangming Chen & Zhimei Gao & Shuai Li & Yanyan Chen & Chenhui Huang & Juan Chen & Zhengjun Chen & Ming Lei & Qian Bian, 2021. "Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment," Nature Communications, Nature, vol. 12(1), pages 1-20, December.

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