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Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

Author

Listed:
  • Kunyoo Shin

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

  • John Lee

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Nini Guo

    (Johns Hopkins University School of Medicine)

  • James Kim

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Agnes Lim

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Lishu Qu

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Indira U. Mysorekar

    (Washington University School of Medicine)

  • Philip A. Beachy

    (Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine)

Abstract

Signalling epidermal growth The maintenance and regeneration of the adult bladder epithelium is poorly understood, yet it is clinically relevant to the development of urinary-tract infections and bladder cancer. A new study provides insight into the cellular and molecular mechanisms underlying the regenerative response to injury within the mammalian urinary bladder. On injury by bacterial infection or chemical agents, a Shh and Wnt signalling feedback circuit between basal cells of the urothelium and the stromal cells that underlie them leads to regenerative proliferation of the bladder epithelia.

Suggested Citation

  • Kunyoo Shin & John Lee & Nini Guo & James Kim & Agnes Lim & Lishu Qu & Indira U. Mysorekar & Philip A. Beachy, 2011. "Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder," Nature, Nature, vol. 472(7341), pages 110-114, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7341:d:10.1038_nature09851
    DOI: 10.1038/nature09851
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    Cited by:

    1. Tiffany Tate & Tina Xiang & Sarah E. Wobker & Mi Zhou & Xiao Chen & Hyunwoo Kim & Ekatherina Batourina & Chyuan-Sheng Lin & William Y. Kim & Chao Lu & James M. Mckiernan & Cathy Lee Mendelsohn, 2021. "Pparg signaling controls bladder cancer subtype and immune exclusion," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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