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Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

Author

Listed:
  • Linda M. Wakim

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

  • Michael J. Bevan

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

Abstract

A prompt response to viral infection A novel mechanism for the activation of naive CD8+ T cells was identified in 2005. Termed cross-dressing, in recognition of the cross-priming and direct priming mechanisms known previously, it involves the transfer of loaded MHC/peptide molecules from an infected cell to dendritic cells. Linda Wakim and Michael Bevan now show that memory T-cell activation in viral infection occurs in part through cross-dressing. As an alternative mode of antigen presentation to memory T cells during viral infection, cross-dressing avoids the need for antigen processing by the presenting dendritic cell and allows prompt presentation of peptide epitopes that closely reflect those expressed on infected cells.

Suggested Citation

  • Linda M. Wakim & Michael J. Bevan, 2011. "Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection," Nature, Nature, vol. 471(7340), pages 629-632, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7340:d:10.1038_nature09863
    DOI: 10.1038/nature09863
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    1. Kaiyuan Wang & Xuanbo Zhang & Hao Ye & Xia Wang & Zhijin Fan & Qi Lu & Songhao Li & Jian Zhao & Shunzhe Zheng & Zhonggui He & Qianqian Ni & Xiaoyuan Chen & Jin Sun, 2023. "Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Isabelle Jia-Hui Foo & Brendon Y. Chua & E. Bridie Clemens & So Young Chang & Xiaoxiao Jia & Hayley A. McQuilten & Ashley Huey Yiing Yap & Aira F. Cabug & Mitra Ashayeripanah & Hamish E. G. McWilliam , 2024. "Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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