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The structural basis of agonist-induced activation in constitutively active rhodopsin

Author

Listed:
  • Jörg Standfuss

    (Paul Scherrer Institut
    MRC Laboratory of Molecular Biology)

  • Patricia C. Edwards

    (MRC Laboratory of Molecular Biology)

  • Aaron D’Antona

    (Brandeis University)

  • Maikel Fransen

    (Paul Scherrer Institut)

  • Guifu Xie

    (Brandeis University)

  • Daniel D. Oprian

    (Brandeis University)

  • Gebhard F. X. Schertler

    (Paul Scherrer Institut
    MRC Laboratory of Molecular Biology)

Abstract

Rhodopsin activation Structural studies of active states of the visual pigment rhodopsin, a G protein-coupled receptor, have previously been limited to apoprotein or opsin forms that do not contain the agonist all-trans-retinal. Two groups now report structures that reveal more details of the transformations involved in rhodopsin activation. Choe et al. solve the X-ray crystal structure of the metarhodopsin II intermediate of the photoreceptor rhodopsin, and Standfuss et al. determine the structure of a constitutively active mutant of rhodopsin bound to a peptide derived from the C-terminus of the G protein transducin.

Suggested Citation

  • Jörg Standfuss & Patricia C. Edwards & Aaron D’Antona & Maikel Fransen & Guifu Xie & Daniel D. Oprian & Gebhard F. X. Schertler, 2011. "The structural basis of agonist-induced activation in constitutively active rhodopsin," Nature, Nature, vol. 471(7340), pages 656-660, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7340:d:10.1038_nature09795
    DOI: 10.1038/nature09795
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    Cited by:

    1. Geng Chen & Jun Xu & Asuka Inoue & Maximilian F. Schmidt & Chen Bai & Qiuyuan Lu & Peter Gmeiner & Zheng Liu & Yang Du, 2022. "Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Valérie Capra & Marta Busnelli & Alessandro Perenna & Manuela Ambrosio & Maria Rosa Accomazzo & Celine Galés & Bice Chini & G Enrico Rovati, 2013. "Full and Partial Agonists of Thromboxane Prostanoid Receptor Unveil Fine Tuning of Receptor Superactive Conformation and G Protein Activation," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-12, March.

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