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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

Author

Listed:
  • Rachel Litman Flynn

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Richard C. Centore

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Roderick J. O’Sullivan

    (Molecular and Cellular Laboratory, The Salk Institute for Biological Studies)

  • Rekha Rai

    (Yale University School of Medicine)

  • Alice Tse

    (Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Zhou Songyang

    (Baylor College of Medicine)

  • Sandy Chang

    (Yale University School of Medicine)

  • Jan Karlseder

    (Molecular and Cellular Laboratory, The Salk Institute for Biological Studies)

  • Lee Zou

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Harvard Medical School)

Abstract

POT1 and RPA go their separate ways Two single-stranded DNA binding proteins, POT1 and RPA, associate with the ends of DNA chromosomes, which are known as telomeres. Binding of RPA to telomeres can activate a DNA damage response, so it was suggested that POT1 might bind telomeres to prevent RPA association. Zou and colleagues unexpectedly find that POT1 and its partner TPP1 do not prevent RPA binding, but hnRNPA1 does. TERRA, a telomere-associated RNA, displaces hnRNPA1 and promotes POT1 binding after S phase, when replication is completed.

Suggested Citation

  • Rachel Litman Flynn & Richard C. Centore & Roderick J. O’Sullivan & Rekha Rai & Alice Tse & Zhou Songyang & Sandy Chang & Jan Karlseder & Lee Zou, 2011. "TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA," Nature, Nature, vol. 471(7339), pages 532-536, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7339:d:10.1038_nature09772
    DOI: 10.1038/nature09772
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    Cited by:

    1. Meng Xu & Dulmi Senanayaka & Rongwei Zhao & Tafadzwa Chigumira & Astha Tripathi & Jason Tones & Rachel M. Lackner & Anne R. Wondisford & Laurel N. Moneysmith & Alexander Hirschi & Sara Craig & Sahar A, 2024. "TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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