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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

Author

Listed:
  • William J. Kaiser

    (Emory Vaccine Center, Emory University School of Medicine)

  • Jason W. Upton

    (Emory Vaccine Center, Emory University School of Medicine)

  • Alyssa B. Long

    (Emory University)

  • Devon Livingston-Rosanoff

    (Emory Vaccine Center, Emory University School of Medicine)

  • Lisa P. Daley-Bauer

    (Emory Vaccine Center, Emory University School of Medicine)

  • Razqallah Hakem

    (University of Toronto and Ontario Cancer Institute, University Health Network)

  • Tamara Caspary

    (Emory University)

  • Edward S. Mocarski

    (Emory Vaccine Center, Emory University School of Medicine)

Abstract

Caspase-8 joins RIPK at the death Caspase-8 mediates apoptosis induced by 'death receptors' on the cell's surface. At the same time, it is able to prevent receptor interacting protein kinase (RIPK)-dependent necrosis. Without caspase-8, mice die during embryonic development, but why this happens is not clear. Two groups show that this lethality is not caused by the absence of apoptosis, but by the RIPK3-dependent necrosis that is unleashed without caspase-8. Mice lacking both caspase-8 and RIP3 develop into viable, immunocompetent adults, but have a progressive lymphoaccumulative disease similar to that in mice that lack the CD95 death receptor. Oberst et al. also show that caspase-8 forms a proteolytically active complex with FLICE-like inhibitory protein long (FLIPL), and that this complex is required for protection against RIP3-dependent necrosis.

Suggested Citation

  • William J. Kaiser & Jason W. Upton & Alyssa B. Long & Devon Livingston-Rosanoff & Lisa P. Daley-Bauer & Razqallah Hakem & Tamara Caspary & Edward S. Mocarski, 2011. "RIP3 mediates the embryonic lethality of caspase-8-deficient mice," Nature, Nature, vol. 471(7338), pages 368-372, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09857
    DOI: 10.1038/nature09857
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    Cited by:

    1. Chao-Yu Yang & Yi-Chun Tseng & Yi-Fan Tu & Bai-Jiun Kuo & Li-Chung Hsu & Chia-I Lien & You-Sheng Lin & Yin-Ting Wang & Yen-Chen Lu & Tsung-Wei Su & Yu-Chih Lo & Su-Chang Lin, 2024. "Reverse hierarchical DED assembly in the cFLIP-procaspase-8 and cFLIP-procaspase-8-FADD complexes," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Esther Hoste & Kim Lecomte & Karl Annusver & Niels Vandamme & Jana Roels & Sophia Maschalidi & Lien Verboom & Hanna-Kaisa Vikkula & Mozes Sze & Lisette Van Hove & Kevin Verstaen & Arne Martens & Tino , 2021. "OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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