IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v471y2011i7338d10.1038_nature09754.html
   My bibliography  Save this article

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

Author

Listed:
  • Christian Steidl

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Sohrab P. Shah

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Bruce W. Woolcock

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Lixin Rui

    (Metabolism Branch, Center for Cancer Research, National Cancer Institute)

  • Masahiro Kawahara

    (Albert Einstein College of Medicine)

  • Pedro Farinha

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Nathalie A. Johnson

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Yongjun Zhao

    (Genome Sciences Centre, BC Cancer Agency)

  • Adele Telenius

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Susana Ben Neriah

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Andrew McPherson

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Barbara Meissner

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Ujunwa C. Okoye

    (Albert Einstein College of Medicine)

  • Arjan Diepstra

    (University Medical Center Groningen, University of Groningen)

  • Anke van den Berg

    (University Medical Center Groningen, University of Groningen)

  • Mark Sun

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Gillian Leung

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Steven J. Jones

    (Genome Sciences Centre, BC Cancer Agency)

  • Joseph M. Connors

    (BC Cancer Agency Centre for Lymphoid Cancer)

  • David G. Huntsman

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Kerry J. Savage

    (BC Cancer Agency Centre for Lymphoid Cancer)

  • Lisa M. Rimsza

    (University of Arizona)

  • Douglas E. Horsman

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

  • Louis M. Staudt

    (Metabolism Branch, Center for Cancer Research, National Cancer Institute)

  • Ulrich Steidl

    (Albert Einstein College of Medicine)

  • Marco A. Marra

    (Genome Sciences Centre, BC Cancer Agency
    University of British Columbia)

  • Randy D. Gascoyne

    (Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG))

Abstract

MHC regulator in cancers Using whole transcriptome sequencing, Steidl et al. identify recurrent gene translocations in B-cell lymphomas that involve the class II transactivator CIITA, the 'master regulator' of the major histocompatibility complex. These translocations downregulate cell surface HLA class II and, with some fusion partners, lead to overexpression of CD274/CD273 ligands, potentially reducing the anti-tumour immune response against these lymphomas. Recurrent rearrangements of CIITA may represent a genetic mechanism that is involved more widely in interactions between tumours and their microenvironment in lymphoid cancers.

Suggested Citation

  • Christian Steidl & Sohrab P. Shah & Bruce W. Woolcock & Lixin Rui & Masahiro Kawahara & Pedro Farinha & Nathalie A. Johnson & Yongjun Zhao & Adele Telenius & Susana Ben Neriah & Andrew McPherson & Bar, 2011. "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers," Nature, Nature, vol. 471(7338), pages 377-381, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09754
    DOI: 10.1038/nature09754
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09754
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09754?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Heng-Jia Liu & Heng Du & Damir Khabibullin & Mahsa Zarei & Kevin Wei & Gordon J. Freeman & David J. Kwiatkowski & Elizabeth P. Henske, 2023. "mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09754. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.