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CREBBP mutations in relapsed acute lymphoblastic leukaemia

Author

Listed:
  • Charles G. Mullighan

    (St Jude Children’s Research Hospital)

  • Jinghui Zhang

    (St Jude Children’s Research Hospital)

  • Lawryn H. Kasper

    (St Jude Children’s Research Hospital)

  • Stephanie Lerach

    (St Jude Children’s Research Hospital)

  • Debbie Payne-Turner

    (St Jude Children’s Research Hospital)

  • Letha A. Phillips

    (St Jude Children’s Research Hospital)

  • Sue L. Heatley

    (St Jude Children’s Research Hospital)

  • Linda Holmfeldt

    (St Jude Children’s Research Hospital)

  • J. Racquel Collins-Underwood

    (St Jude Children’s Research Hospital)

  • Jing Ma

    (The Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital)

  • Kenneth H. Buetow

    (National Cancer Institute Center for Bioinformatics, National Cancer Institute
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health)

  • Ching-Hon Pui

    (St Jude Children’s Research Hospital)

  • Sharyn D. Baker

    (St Jude Children’s Research Hospital)

  • Paul K. Brindle

    (St Jude Children’s Research Hospital)

  • James R. Downing

    (St Jude Children’s Research Hospital)

Abstract

CREBBP and EP300 mutations in B-cell lymphoma In three different subtypes of B-cell lymphomas, two papers report frequent somatic mutations in the genes CREBBP and EP300, which are present in primary tumours or acquired at relapse. These genes encode related acetyltransferases that mainly function to regulate gene expression by acetylating histones and other transcriptional regulators. The mutations disrupt these activities and thus alter chromatin regulation of gene expression, as well as proliferation and potentially the response to anticancer drugs. These studies may provide a rationale for the use of histone deacetylase inhibitors in certain B-cell lymphomas.

Suggested Citation

  • Charles G. Mullighan & Jinghui Zhang & Lawryn H. Kasper & Stephanie Lerach & Debbie Payne-Turner & Letha A. Phillips & Sue L. Heatley & Linda Holmfeldt & J. Racquel Collins-Underwood & Jing Ma & Kenne, 2011. "CREBBP mutations in relapsed acute lymphoblastic leukaemia," Nature, Nature, vol. 471(7337), pages 235-239, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7337:d:10.1038_nature09727
    DOI: 10.1038/nature09727
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    Cited by:

    1. Longxia Xu & Hongwen Xuan & Wei He & Liang Zhang & Mengying Huang & Kuai Li & Hong Wen & Han Xu & Xiaobing Shi, 2023. "TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Han Wang & Huiying Sun & Bilin Liang & Fang Zhang & Fan Yang & Bowen Cui & Lixia Ding & Xiang Wang & Ronghua Wang & Jiaoyang Cai & Yanjing Tang & Jianan Rao & Wenting Hu & Shuang Zhao & Wenyan Wu & Xi, 2023. "Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Jolanda Sarno & Pablo Domizi & Yuxuan Liu & Milton Merchant & Christina Bligaard Pedersen & Dorra Jedoui & Astraea Jager & Garry P. Nolan & Giuseppe Gaipa & Sean C. Bendall & Felice-Alessio Bava & Kar, 2023. "Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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