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A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

Author

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  • Huimin Zhang

    (Development and Stem Cells Program, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France)

  • Frédéric Landmann

    (Development and Stem Cells Program, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France
    Present address: MCBD Department, University of California, Santa Cruz, California 95064, USA .)

  • Hala Zahreddine

    (Development and Stem Cells Program, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France)

  • David Rodriguez

    (Development and Stem Cells Program, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France)

  • Marc Koch

    (Imaging Centre, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France)

  • Michel Labouesse

    (Development and Stem Cells Program, IGBMC, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France)

Abstract

Pulled into shape The development and function of many organs depend not only on biochemical signals, but also on the ability of cells and tissues to respond biochemically to mechanical forces — mechanotransduction. Here, Michel Labouesse and colleagues describe a mechanotransduction pathway that links the body wall with the epidermis in the roundworm Caenorhabditis elegans. The pathway involves the p21-activated kinase PAK-1, an adaptor GIT-1 and its partner PIX-1. Tension exerted by muscles or external pressure keeps GIT-1 on station at hemidesmosomes — the small rivet-like bodies that attach epidermal cells to the underlying musculature — and stimulates PAK-1 through PIX-1 and Rac GTPase. The C. elegans hemidesmosome is therefore more than a passive attachment structure — it is a sensor that responds to tension by triggering signalling processes.

Suggested Citation

  • Huimin Zhang & Frédéric Landmann & Hala Zahreddine & David Rodriguez & Marc Koch & Michel Labouesse, 2011. "A tension-induced mechanotransduction pathway promotes epithelial morphogenesis," Nature, Nature, vol. 471(7336), pages 99-103, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7336:d:10.1038_nature09765
    DOI: 10.1038/nature09765
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    Cited by:

    1. L. Angela Mihai & Khulud Alayyash & Hayley Wyatt, 2017. "The optimal density of cellular solids in axial tension," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(7), pages 701-713, May.
    2. Andrea Braeutigam & Ahmet Nihat Simsek & Gerhard Gompper & Benedikt Sabass, 2022. "Generic self-stabilization mechanism for biomolecular adhesions under load," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Alina C. Teuscher & Cyril Statzer & Anita Goyala & Seraina A. Domenig & Ingmar Schoen & Max Hess & Alexander M. Hofer & Andrea Fossati & Viola Vogel & Orcun Goksel & Ruedi Aebersold & Collin Y. Ewald, 2024. "Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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