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Programming the magnitude and persistence of antibody responses with innate immunity

Author

Listed:
  • Sudhir Pai Kasturi

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Ioanna Skountzou

    (Emory Vaccine Center, Emory University
    Emory University)

  • Randy A. Albrecht

    (Mount Sinai School of Medicine)

  • Dimitrios Koutsonanos

    (Emory University)

  • Tang Hua

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Helder I. Nakaya

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Rajesh Ravindran

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Shelley Stewart

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Munir Alam

    (Duke Human Vaccine Institute, Duke University Medical Center)

  • Marcin Kwissa

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Francois Villinger

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University
    Emory University School of Medicine)

  • Niren Murthy

    (Georgia Institute of Technology)

  • John Steel

    (Mount Sinai School of Medicine)

  • Joshy Jacob

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University
    Emory University)

  • Robert J. Hogan

    (College of Veterinary Medicine, University of Georgia)

  • Adolfo García-Sastre

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine
    Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine)

  • Richard Compans

    (Emory Vaccine Center, Emory University
    Emory University)

  • Bali Pulendran

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University
    Emory University School of Medicine)

Abstract

Vaccines given a boost A feature of many successful vaccines is the induction of memory B cells and long-lived plasma cells that can secrete neutralizing antibodies for a lifetime. The mechanisms that stimulate such persistent responses remain poorly understood. Bali Pulendran and colleagues show that nanoparticles containing two Toll-like receptor ligands, proteins with important roles in innate immunity, can boost the magnitude and persistence of vaccine-elicited antibody responses in primates, improving vaccine-mediated protection against influenza virus.

Suggested Citation

  • Sudhir Pai Kasturi & Ioanna Skountzou & Randy A. Albrecht & Dimitrios Koutsonanos & Tang Hua & Helder I. Nakaya & Rajesh Ravindran & Shelley Stewart & Munir Alam & Marcin Kwissa & Francois Villinger &, 2011. "Programming the magnitude and persistence of antibody responses with innate immunity," Nature, Nature, vol. 470(7335), pages 543-547, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09737
    DOI: 10.1038/nature09737
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    Cited by:

    1. Jonathan H. Lam & Nicole Baumgarth, 2023. "Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Joshua Gillard & Madeleine Suffiotti & Peter Brazda & Prashanna B. Venkatasubramanian & Pauline Versteegen & Marien I. Jonge & Dominic Kelly & Sagida Bibi & Marta Valente Pinto & Elles Simonetti & Mih, 2024. "Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Leonardo B. Furstenau & Bruna Rabaioli & Michele Kremer Sott & Danielli Cossul & Mariluza Sott Bender & Eduardo Moreno Júdice De Mattos Farina & Fabiano Novaes Barcellos Filho & Priscilla Paola Severo, 2021. "A Bibliometric Network Analysis of Coronavirus during the First Eight Months of COVID-19 in 2020," IJERPH, MDPI, vol. 18(3), pages 1-24, January.

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