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The novel gene twenty-four defines a critical translational step in the Drosophila clock

Author

Listed:
  • Chunghun Lim

    (Northwestern University)

  • Jongbin Lee

    (Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea)

  • Changtaek Choi

    (Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea)

  • Valerie L. Kilman

    (Northwestern University)

  • Juwon Kim

    (Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea)

  • Sung Mi Park

    (Pohang University of Science and Technology, Pohang 790-784, Korea)

  • Sung Key Jang

    (Pohang University of Science and Technology, Pohang 790-784, Korea)

  • Ravi Allada

    (Northwestern University)

  • Joonho Choe

    (Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea)

Abstract

Fly by night — and day Gene expression in multicellular organisms fluctuates in line with the day/night cycle, resulting in differential behaviours throughout the day. These changes in expression have been widely studied at the transcriptional and post-translational levels. A further type of circadian-influenced regulation has now been identified in the fruitfly Drosophila. A gene termed twenty-four (twf) is shown to have a role in an under-appreciated aspect of the clock pathway, the translation of a clock component from RNA to protein. The twenty-four protein associates with the mRNA of the clock protein PER, enhancing its translation.

Suggested Citation

  • Chunghun Lim & Jongbin Lee & Changtaek Choi & Valerie L. Kilman & Juwon Kim & Sung Mi Park & Sung Key Jang & Ravi Allada & Joonho Choe, 2011. "The novel gene twenty-four defines a critical translational step in the Drosophila clock," Nature, Nature, vol. 470(7334), pages 399-403, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09728
    DOI: 10.1038/nature09728
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    Cited by:

    1. Esteban J Beckwith & E Axel Gorostiza & Jimena Berni & Carolina Rezával & Agustín Pérez-Santángelo & Alejandro D Nadra & María Fernanda Ceriani, 2013. "Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway," PLOS Biology, Public Library of Science, vol. 11(12), pages 1-15, December.
    2. Paula S Nieto & Jorge A Revelli & Eduardo Garbarino-Pico & Carlos A Condat & Mario E Guido & Francisco A Tamarit, 2015. "Effects of Different PER Translational Kinetics on the Dynamics of a Core Circadian Clock Model," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-27, January.

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