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CKIα ablation highlights a critical role for p53 in invasiveness control

Author

Listed:
  • Ela Elyada

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Ariel Pribluda

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Robert E. Goldstein

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Yael Morgenstern

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Guy Brachya

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Gady Cojocaru

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Irit Snir-Alkalay

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Ido Burstain

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Rebecca Haffner-Krausz

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Steffen Jung

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zoltan Wiener

    (Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland)

  • Kari Alitalo

    (Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland)

  • Moshe Oren

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Eli Pikarsky

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
    IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Yinon Ben-Neriah

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

Abstract

The role of p53 in metastasis In a mouse model of intestinal cancer, Yinon Ben-Neriah and colleagues show that in the absence of CK1-α, the loss of p53 dramatically enhances tumour progression and metastasis. The tumour repressor p53 normally limits cancer cell invasion through the regulation of p21 and a set of invasion genes that include Prox1. This study adds more detail to the emerging picture that during tumour development, the p53 gene not only controls cell death and proliferation but also metastasis.

Suggested Citation

  • Ela Elyada & Ariel Pribluda & Robert E. Goldstein & Yael Morgenstern & Guy Brachya & Gady Cojocaru & Irit Snir-Alkalay & Ido Burstain & Rebecca Haffner-Krausz & Steffen Jung & Zoltan Wiener & Kari Ali, 2011. "CKIα ablation highlights a critical role for p53 in invasiveness control," Nature, Nature, vol. 470(7334), pages 409-413, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09673
    DOI: 10.1038/nature09673
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    Cited by:

    1. Tingting Niu & Charlotte Rosny & Séverine Chautard & Amaury Rey & Danish Patoli & Marine Groslambert & Camille Cosson & Brice Lagrange & Zhirong Zhang & Orane Visvikis & Sabine Hacot & Maggy Hologne &, 2021. "NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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