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Single mimivirus particles intercepted and imaged with an X-ray laser

Author

Listed:
  • M. Marvin Seibert

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Tomas Ekeberg

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Filipe R. N. C. Maia

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Martin Svenda

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Jakob Andreasson

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Olof Jönsson

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Duško Odić

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Bianca Iwan

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Andrea Rocker

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Daniel Westphal

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Max Hantke

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

  • Daniel P. DePonte

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Anton Barty

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Joachim Schulz

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Lars Gumprecht

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Nicola Coppola

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Andrew Aquila

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Mengning Liang

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Thomas A. White

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Andrew Martin

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Carl Caleman

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden
    Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Stephan Stern

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
    University of Hamburg, Notkestrasse 85, 22607 Hamburg, Germany)

  • Chantal Abergel

    (Information Génomique et Structurale, CNRS-UPR2589, Aix-Marseille Université, Institut de Microbiologie de la Méditerranée, Parc Scientifique de Luminy, Case 934, 13288 Marseille Cedex 9, France)

  • Virginie Seltzer

    (Information Génomique et Structurale, CNRS-UPR2589, Aix-Marseille Université, Institut de Microbiologie de la Méditerranée, Parc Scientifique de Luminy, Case 934, 13288 Marseille Cedex 9, France)

  • Jean-Michel Claverie

    (Information Génomique et Structurale, CNRS-UPR2589, Aix-Marseille Université, Institut de Microbiologie de la Méditerranée, Parc Scientifique de Luminy, Case 934, 13288 Marseille Cedex 9, France)

  • Christoph Bostedt

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • John D. Bozek

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Sébastien Boutet

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • A. Alan Miahnahri

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Marc Messerschmidt

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Jacek Krzywinski

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Garth Williams

    (LCLS, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Keith O. Hodgson

    (PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Michael J. Bogan

    (PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Christina Y. Hampton

    (PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Raymond G. Sierra

    (PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Dmitri Starodub

    (PULSE Institute, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA)

  • Inger Andersson

    (Swedish University of Agricultural Sciences, Uppsala Biomedical Centre, Box 590, S-751 24 Uppsala, Sweden)

  • Saša Bajt

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Miriam Barthelmess

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • John C. H. Spence

    (PSF470, Arizona State University)

  • Petra Fromme

    (Arizona State University)

  • Uwe Weierstall

    (PSF470, Arizona State University)

  • Richard Kirian

    (PSF470, Arizona State University)

  • Mark Hunter

    (Arizona State University)

  • R. Bruce Doak

    (PSF470, Arizona State University)

  • Stefano Marchesini

    (Advanced Light Source, Lawrence Berkeley National Laboratory)

  • Stefan P. Hau-Riege

    (Lawrence Livermore National Laboratory, 7000 East Avenue, Mail Stop L-211, Livermore, California 94551, USA)

  • Matthias Frank

    (Lawrence Livermore National Laboratory, 7000 East Avenue, Mail Stop L-211, Livermore, California 94551, USA)

  • Robert L. Shoeman

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Lukas Lomb

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Sascha W. Epp

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Robert Hartmann

    (PNSensor GmbH, Römerstrasse 28, 80803 München, Germany)

  • Daniel Rolles

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany)

  • Artem Rudenko

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Carlo Schmidt

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Lutz Foucar

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany)

  • Nils Kimmel

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Peter Holl

    (PNSensor GmbH, Römerstrasse 28, 80803 München, Germany)

  • Benedikt Rudek

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Benjamin Erk

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • André Hömke

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Christian Reich

    (PNSensor GmbH, Römerstrasse 28, 80803 München, Germany)

  • Daniel Pietschner

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Georg Weidenspointner

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Lothar Strüder

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany
    Universität Siegen, Emmy-Noether Campus, Walter Flex Strasse 3, 57068 Siegen, Germany)

  • Günter Hauser

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Hubert Gorke

    (Forschungszentrum Jülich, Institut ZEL, 52425 Jülich, Germany)

  • Joachim Ullrich

    (Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Ilme Schlichting

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany)

  • Sven Herrmann

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Gerhard Schaller

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Florian Schopper

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Heike Soltau

    (PNSensor GmbH, Römerstrasse 28, 80803 München, Germany)

  • Kai-Uwe Kühnel

    (Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Robert Andritschke

    (Max-Planck-Institut Halbleiterlabor, Otto-Hahn-Ring 6, 81739 München, Germany
    Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstrasse, 85741 Garching, Germany)

  • Claus-Dieter Schröter

    (Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany)

  • Faton Krasniqi

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Max Planck Advanced Study Group, Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg, Germany)

  • Mario Bott

    (Max-Planck-Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany)

  • Sebastian Schorb

    (Institut für Optik und Atomare Physik, Technische Universität Berlin, Hardenbergstrasse 36, 10623 Berlin, Germany)

  • Daniela Rupp

    (Institut für Optik und Atomare Physik, Technische Universität Berlin, Hardenbergstrasse 36, 10623 Berlin, Germany)

  • Marcus Adolph

    (Institut für Optik und Atomare Physik, Technische Universität Berlin, Hardenbergstrasse 36, 10623 Berlin, Germany)

  • Tais Gorkhover

    (Institut für Optik und Atomare Physik, Technische Universität Berlin, Hardenbergstrasse 36, 10623 Berlin, Germany)

  • Helmut Hirsemann

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Guillaume Potdevin

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Heinz Graafsma

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Björn Nilsson

    (Photon Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany)

  • Henry N. Chapman

    (Center for Free-Electron Laser Science, DESY, Notkestrasse 85, 22607 Hamburg, Germany
    University of Hamburg, Notkestrasse 85, 22607 Hamburg, Germany)

  • Janos Hajdu

    (Laboratory of Molecular Biophysics, Uppsala University, Husargatan 3 (Box 596), SE-751 24 Uppsala, Sweden)

Abstract

Biological imaging with the LCLS X-ray laser The start-up of the Linac Coherent Light Source (LCLS), the new femtosecond hard X-ray laser facility in Stanford, California, has brought high expectations of a new era for biological imaging. The intense, ultrashort X-ray pulses allow diffraction imaging of small structures before radiation damage occurs. Two papers in this issue of Nature present proof-of-concept experiments showing the LCLS in action. Chapman et al. tackle structure determination from nanocrystals of macromolecules that cannot be grown in large crystals. They obtain more than three million diffraction patterns from a stream of nanocrystals of the membrane protein photosystem I, and assemble a three-dimensional data set for this protein. Seibert et al. obtain images of a non-crystalline biological sample, mimivirus, by injecting a beam of cooled mimivirus particles into the X-ray beam.

Suggested Citation

  • M. Marvin Seibert & Tomas Ekeberg & Filipe R. N. C. Maia & Martin Svenda & Jakob Andreasson & Olof Jönsson & Duško Odić & Bianca Iwan & Andrea Rocker & Daniel Westphal & Max Hantke & Daniel P. DePonte, 2011. "Single mimivirus particles intercepted and imaged with an X-ray laser," Nature, Nature, vol. 470(7332), pages 78-81, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7332:d:10.1038_nature09748
    DOI: 10.1038/nature09748
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    1. Stephan Kuschel & Phay J. Ho & Andre Al Haddad & Felix F. Zimmermann & Leonie Flueckiger & Matthew R. Ware & Joseph Duris & James P. MacArthur & Alberto Lutman & Ming-Fu Lin & Xiang Li & Kazutaka Naka, 2025. "Non-linear enhancement of ultrafast X-ray diffraction through transient resonances," Nature Communications, Nature, vol. 16(1), pages 1-8, December.

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