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Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

Author

Listed:
  • Cuong Q. Diep

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Dongdong Ma

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Rahul C. Deo

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Teresa M. Holm

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Richard W. Naylor

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School)

  • Natasha Arora

    (Center for Regenerative Medicine, Massachusetts General Hospital)

  • Rebecca A. Wingert

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School
    Harvard Stem Cell Institute)

  • Frank Bollig

    (Leibniz Institute for Age Research, Fritz Lipmann Institute)

  • Gordana Djordjevic

    (Center for Regenerative Medicine, Massachusetts General Hospital)

  • Benjamin Lichman

    (Center for Regenerative Medicine, Massachusetts General Hospital)

  • Hao Zhu

    (Dana-Farber Cancer Institute)

  • Takanori Ikenaga

    (Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism)

  • Fumihito Ono

    (Section on Model Synaptic Systems, Laboratory of Molecular Physiology, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism)

  • Christoph Englert

    (Leibniz Institute for Age Research, Fritz Lipmann Institute
    Friedrich-Schiller-University)

  • Chad A. Cowan

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School
    Harvard Stem Cell Institute
    Harvard University)

  • Neil A. Hukriede

    (University of Pittsburgh, School of Medicine)

  • Robert I. Handin

    (Harvard Medical School
    Brigham and Women’s Hospital
    Harvard Stem Cell Institute)

  • Alan J. Davidson

    (Center for Regenerative Medicine, Massachusetts General Hospital
    Harvard Medical School
    Harvard Stem Cell Institute
    Present address: Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland 1142, New Zealand.)

Abstract

Adult kidney regeneration Fish can regenerate nephrons — the functional units of the kidney — following kidney injury, whereas adult mammals lack this ability. A previously unknown type of kidney cell responsible for this regeneration has now been discovered in adult zebrafish, where they are found in small aggregations throughout the kidney. When as few as 10–20 of these progenitor cells are transplanted into injured adult kidneys, they engraft and form new, functional nephrons. This suggests that it might be possible to identify an equivalent regenerative cell in humans for therapeutic purposes.

Suggested Citation

  • Cuong Q. Diep & Dongdong Ma & Rahul C. Deo & Teresa M. Holm & Richard W. Naylor & Natasha Arora & Rebecca A. Wingert & Frank Bollig & Gordana Djordjevic & Benjamin Lichman & Hao Zhu & Takanori Ikenaga, 2011. "Identification of adult nephron progenitors capable of kidney regeneration in zebrafish," Nature, Nature, vol. 470(7332), pages 95-100, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7332:d:10.1038_nature09669
    DOI: 10.1038/nature09669
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    Cited by:

    1. Chi Liu & Xiaoliang Liu & Zhongwei He & Jiangping Zhang & Xiaoqin Tan & Wenmin Yang & Yunfeng Zhang & Ting Yu & Shuyi Liao & Lu Dai & Zhi Xu & Furong Li & Yinghui Huang & Jinghong Zhao, 2023. "Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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