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Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system

Author

Listed:
  • Takeo Horie

    (Shimoda Marine Research Center, University of Tsukuba)

  • Ryoko Shinki

    (Shimoda Marine Research Center, University of Tsukuba)

  • Yosuke Ogura

    (Shimoda Marine Research Center, University of Tsukuba)

  • Takehiro G. Kusakabe

    (Konan University)

  • Nori Satoh

    (Marine Genomics Unit, Okinawa Institute of Science and Technology Promotion Corporation)

  • Yasunori Sasakura

    (Shimoda Marine Research Center, University of Tsukuba)

Abstract

Novel stem cells in the sea squirt Many aspects of the lives of the tunicates, the closest living relatives of the vertebrates, are poorly understood. It was thought that in ascidian tunicates such as the sea squirt (Ciona intestinalis), the superficially vertebrate-like central nervous system of the 'tadpole' larva degenerates to be replaced by an adult nervous system developed from scratch. Transgenesis and imaging techniques now show that this is not the case. In fact, the adult nervous system develops from stem-cell-like ependymal cells found in the larva.

Suggested Citation

  • Takeo Horie & Ryoko Shinki & Yosuke Ogura & Takehiro G. Kusakabe & Nori Satoh & Yasunori Sasakura, 2011. "Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system," Nature, Nature, vol. 469(7331), pages 525-528, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09631
    DOI: 10.1038/nature09631
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    Cited by:

    1. Kushal Kolar & Daniel Dondorp & Jordi Cornelis Zwiggelaar & Jørgen Høyer & Marios Chatzigeorgiou, 2021. "Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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