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Pervasive roles of microRNAs in cardiovascular biology

Author

Listed:
  • Eric M. Small

    (University of Texas Southwestern Medical Center)

  • Eric N. Olson

    (University of Texas Southwestern Medical Center)

Abstract

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

Suggested Citation

  • Eric M. Small & Eric N. Olson, 2011. "Pervasive roles of microRNAs in cardiovascular biology," Nature, Nature, vol. 469(7330), pages 336-342, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7330:d:10.1038_nature09783
    DOI: 10.1038/nature09783
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    Cited by:

    1. Kenny Schlosser & Lauralyn A McIntyre & R James White & Duncan J Stewart, 2015. "Customized Internal Reference Controls for Improved Assessment of Circulating MicroRNAs in Disease," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-22, May.
    2. Ray M Marín & Jiří Vaníček, 2012. "Optimal Use of Conservation and Accessibility Filters in MicroRNA Target Prediction," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
    3. Karen Huen & Daneida Lizarraga & Katherine Kogut & Brenda Eskenazi & Nina Holland, 2019. "Age-Related Differences in miRNA Expression in Mexican-American Newborns and Children," IJERPH, MDPI, vol. 16(4), pages 1-15, February.
    4. Cao Wang & Shupei Qiao & Yufang Zhao & Hui Tian & Wei Yan & Xiaolu Hou & Ruiqi Wang & Bosong Zhang & Chaofan Yang & Fuxing Zhu & Yanwen Jiao & Jiaming Jin & Yue Chen & Weiming Tian, 2023. "The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Andreas B Gevaert & Isabel Witvrouwen & Christiaan J Vrints & Hein Heidbuchel & Emeline M Van Craenenbroeck & Steven J Van Laere & Amaryllis H Van Craenenbroeck, 2018. "MicroRNA profiling in plasma samples using qPCR arrays: Recommendations for correct analysis and interpretation," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-13, February.
    6. Hongbo Shi & Guangde Zhang & Meng Zhou & Liang Cheng & Haixiu Yang & Jing Wang & Jie Sun & Zhenzhen Wang, 2016. "Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-15, February.

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