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Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

Author

Listed:
  • Bjoern O. Schroeder

    (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen)

  • Zhihong Wu

    (University Hospital Schleswig-Holstein, Campus Kiel)

  • Sabine Nuding

    (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen)

  • Sandra Groscurth

    (Max Planck Institute for Developmental Biology
    Present address: Bruker BioSpin AG, 8117 Fällanden, Switzerland.)

  • Moritz Marcinowski

    (Center for Integrated Protein Science Munich, Technische Universität München)

  • Julia Beisner

    (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen)

  • Johannes Buchner

    (Center for Integrated Protein Science Munich, Technische Universität München)

  • Martin Schaller

    (University Hospital Tübingen)

  • Eduard F. Stange

    (Robert Bosch Hospital)

  • Jan Wehkamp

    (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen
    Robert Bosch Hospital)

Abstract

Human β-defensin 1 shows its true colours Defensins are key effector molecules of innate immunity, protecting the host from infectious microbes and shaping the composition of the microbiota at mucosal surfaces. Human β-defensin 1 (hBD-1) is one of the most prominent peptides of its class and is expressed by virtually all human epithelial sites, but previous work suggested that it has low antibiotic activity when compared with other defensins. Jan Wehkamp and colleagues now show that in reducing conditions similar to those found in the distal colon, hBD-1 exhibits potent antimicrobial action against the potential pathogens Candia albicans, Bifidobacterium and Lactobacillus species. In vitro evidence points to thioredoxin as the reducing agent most likely to unmask hBD-1's antimicrobial activity in the intestinal epithelium.

Suggested Citation

  • Bjoern O. Schroeder & Zhihong Wu & Sabine Nuding & Sandra Groscurth & Moritz Marcinowski & Julia Beisner & Johannes Buchner & Martin Schaller & Eduard F. Stange & Jan Wehkamp, 2011. "Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1," Nature, Nature, vol. 469(7330), pages 419-423, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7330:d:10.1038_nature09674
    DOI: 10.1038/nature09674
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    Cited by:

    1. Alizee Lebeau & Diane Bruyere & Patrick Roncarati & Paul Peixoto & Eric Hervouet & Gael Cobraiville & Bernard Taminiau & Murielle Masson & Carmen Gallego & Gabriel Mazzucchelli & Nicolas Smargiasso & , 2022. "HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Soumitra Mohanty & Witchuda Kamolvit & Andrea Scheffschick & Anneli Björklund & Jonas Tovi & Alexander Espinosa & Kerstin Brismar & Thomas Nyström & Jens M. Schröder & Claes-Göran Östenson & Pontus As, 2022. "Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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