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Atomic-level modelling of the HIV capsid

Author

Listed:
  • Owen Pornillos

    (University of Virginia School of Medicine
    The Scripps Research Institute)

  • Barbie K. Ganser-Pornillos

    (University of Virginia School of Medicine
    The Scripps Research Institute)

  • Mark Yeager

    (University of Virginia School of Medicine
    The Scripps Research Institute
    University of Virginia Health System)

Abstract

The HIV-1 capsid modelled at the atomic level The human immunodeficiency virus 1 (HIV-1) virion has a cone-shaped core composed of capsid proteins, which take either pentameric or hexameric form. Mark Yeager and colleagues had previously solved the crystal structure of the capsid hexamer. Now they provide the structure of the pentamer, which allows them to propose the first atomic-level model of the mature HIV capsid.

Suggested Citation

  • Owen Pornillos & Barbie K. Ganser-Pornillos & Mark Yeager, 2011. "Atomic-level modelling of the HIV capsid," Nature, Nature, vol. 469(7330), pages 424-427, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7330:d:10.1038_nature09640
    DOI: 10.1038/nature09640
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    Cited by:

    1. Ahmed Abdul Quadeer & David Morales-Jimenez & Matthew R McKay, 2018. "Co-evolution networks of HIV/HCV are modular with direct association to structure and function," PLOS Computational Biology, Public Library of Science, vol. 14(9), pages 1-29, September.
    2. Hiroaki Takeuchi & Hideki Saito & Takeshi Noda & Tadashi Miyamoto & Tomokazu Yoshinaga & Kazutaka Terahara & Hiroshi Ishii & Yasuko Tsunetsugu-Yokota & Shoji Yamaoka, 2017. "Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis," PLOS Pathogens, Public Library of Science, vol. 13(7), pages 1-35, July.
    3. Jordy Homing Lam & Aiichiro Nakano & Vsevolod Katritch, 2024. "Scalable computation of anisotropic vibrations for large macromolecular assemblies," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Anna T. Gres & Karen A. Kirby & William M. McFadden & Haijuan Du & Dandan Liu & Chaoyi Xu & Alexander J. Bryer & Juan R. Perilla & Jiong Shi & Christopher Aiken & Xiaofeng Fu & Peijun Zhang & Ashwanth, 2023. "Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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