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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Author

Listed:
  • Mariela Jaskelioff

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Florian L. Muller

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Ji-Hye Paik

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Emily Thomas

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Shan Jiang

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Andrew C. Adams

    (Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Ergun Sahin

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Maria Kost-Alimova

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Alexei Protopopov

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Juan Cadiñanos

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • James W. Horner

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

  • Eleftheria Maratos-Flier

    (Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Ronald A. DePinho

    (Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School)

Abstract

Anti-ageing effect of telomere restoration Loss of telomeres, the protective tips on the ends of chromosomes, causes tissue atrophy and other damage. A growing body of evidence points to telomere defects as a driver of age-associated organ decline and disease. Ronald DePinho and colleagues now show that reactivation of endogenous telomerase in mice extends telomeres, reduces DNA damage signalling, allows resumption of proliferation in quiescent cultures and eliminates degenerative phenotypes in many organs including the brain. Regenerative strategies that restore telomerase integrity may therefore be capable of slowing, halting or reversing age-related tissue degeneration — although as the authors point out, prolonged telomerase reactivation or applications in later life could provoke carcinogenesis.

Suggested Citation

  • Mariela Jaskelioff & Florian L. Muller & Ji-Hye Paik & Emily Thomas & Shan Jiang & Andrew C. Adams & Ergun Sahin & Maria Kost-Alimova & Alexei Protopopov & Juan Cadiñanos & James W. Horner & Eleftheri, 2011. "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice," Nature, Nature, vol. 469(7328), pages 102-106, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7328:d:10.1038_nature09603
    DOI: 10.1038/nature09603
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    Cited by:

    1. Needham, Belinda L. & Adler, Nancy & Gregorich, Steven & Rehkopf, David & Lin, Jue & Blackburn, Elizabeth H. & Epel, Elissa S., 2013. "Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999–2002," Social Science & Medicine, Elsevier, vol. 85(C), pages 1-8.
    2. Natthakan Thongon & Feiyang Ma & Andrea Santoni & Matteo Marchesini & Elena Fiorini & Ashley Rose & Vera Adema & Irene Ganan-Gomez & Emma M. Groarke & Fernanda Gutierrez-Rodrigues & Shuaitong Chen & P, 2021. "Hematopoiesis under telomere attrition at the single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Clifton R. Emery & Qian-Wen Xie & Jessie S. M. Chan & Ling-Li Leng & Celia H. Y. Chan & Kwok-Fai So & Ang Li & Kevin K. T. Po & Zoe Chouliara & Cecilia Lai Wan Chan & Anna W. M. Choi & L. P. Yuen & Ka, 2021. "The Counterintuitive Relationship between Telomerase Activity and Childhood Emotional Abuse: Culture and Complexity," IJERPH, MDPI, vol. 18(4), pages 1-12, February.

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