IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7327d10.1038_nature09710.html
   My bibliography  Save this article

Genetic history of an archaic hominin group from Denisova Cave in Siberia

Author

Listed:
  • David Reich

    (Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Richard E. Green

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    University of California, Santa Cruz 95064, USA)

  • Martin Kircher

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Johannes Krause

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    Institut für Naturwissenschaftliche Archäologie, University of Tübingen, Tübingen 72070, Germany)

  • Nick Patterson

    (Broad Institute of MIT and Harvard)

  • Eric Y. Durand

    (University of California)

  • Bence Viola

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Adrian W. Briggs

    (Harvard Medical School
    Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Udo Stenzel

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Philip L. F. Johnson

    (Emory University)

  • Tomislav Maricic

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Jeffrey M. Good

    (University of Montana)

  • Tomas Marques-Bonet

    (Howard Hughes Medical Institute, University of Washington
    Institute of Evolutionary Biology (UPF-CSIC))

  • Can Alkan

    (Howard Hughes Medical Institute, University of Washington)

  • Qiaomei Fu

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    CAS-MPS Joint Laboratory for Human Evolution and Archeometry, Institute of Vertebrate Paleontology and Paleoanthropology of Chinese Academy of Sciences)

  • Swapan Mallick

    (Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Heng Li

    (Broad Institute of MIT and Harvard)

  • Matthias Meyer

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Evan E. Eichler

    (Howard Hughes Medical Institute, University of Washington)

  • Mark Stoneking

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Michael Richards

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
    University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • Sahra Talamo

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Michael V. Shunkov

    (Institute of Archaeology & Ethnography, Russian Academy of Sciences, Siberian Branch, Novosibirsk 630090, Russia)

  • Anatoli P. Derevianko

    (Institute of Archaeology & Ethnography, Russian Academy of Sciences, Siberian Branch, Novosibirsk 630090, Russia)

  • Jean-Jacques Hublin

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Janet Kelso

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

  • Montgomery Slatkin

    (University of California)

  • Svante Pääbo

    (Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany)

Abstract

Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population ‘Denisovans’ and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

Suggested Citation

  • David Reich & Richard E. Green & Martin Kircher & Johannes Krause & Nick Patterson & Eric Y. Durand & Bence Viola & Adrian W. Briggs & Udo Stenzel & Philip L. F. Johnson & Tomislav Maricic & Jeffrey M, 2010. "Genetic history of an archaic hominin group from Denisova Cave in Siberia," Nature, Nature, vol. 468(7327), pages 1053-1060, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09710
    DOI: 10.1038/nature09710
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09710
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09710?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ralph, Peter L., 2019. "An empirical approach to demographic inference with genomic data," Theoretical Population Biology, Elsevier, vol. 127(C), pages 91-101.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09710. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.