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The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

Author

Listed:
  • Avnish Kapoor

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Matthew S. Goldberg

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Lara K. Cumberland

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Kajan Ratnakumar

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Miguel F. Segura

    (New York University Langone Medical Center
    Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center)

  • Patrick O. Emanuel

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Silvia Menendez

    (New York University Langone Medical Center
    Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center)

  • Chiara Vardabasso

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Gary LeRoy

    (Princeton University, 415 Schultz Laboratory)

  • Claudia I. Vidal

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine
    Present address: Department of Dermatology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA.)

  • David Polsky

    (New York University Langone Medical Center
    New York University Langone Medical Center
    Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center)

  • Iman Osman

    (New York University Langone Medical Center
    Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center)

  • Benjamin A. Garcia

    (Princeton University, 415 Schultz Laboratory)

  • Eva Hernando

    (New York University Langone Medical Center
    Interdisciplinary Melanoma Cooperative Group, New York University Langone Medical Center)

  • Emily Bernstein

    (Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

Abstract

Histone variant lost in melanoma progression The histone variant mH2A is shown to be expressed at reduced levels in many melanomas. Loss of mH2A promotes tumour growth and metastasis, by transcriptional upregulation of CDK8, a known oncogene. This study therefore reveals a new tumour-suppression mechanism exerted by chromatin modification.

Suggested Citation

  • Avnish Kapoor & Matthew S. Goldberg & Lara K. Cumberland & Kajan Ratnakumar & Miguel F. Segura & Patrick O. Emanuel & Silvia Menendez & Chiara Vardabasso & Gary LeRoy & Claudia I. Vidal & David Polsky, 2010. "The histone variant macroH2A suppresses melanoma progression through regulation of CDK8," Nature, Nature, vol. 468(7327), pages 1105-1109, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09590
    DOI: 10.1038/nature09590
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    Cited by:

    1. Jenny Zhe Liao & Hyung-lok Chung & Claire Shih & Kenneth Kin Lam Wong & Debdeep Dutta & Zelha Nil & Catherine Grace Burns & Oguz Kanca & Ye-Jin Park & Zhongyuan Zuo & Paul C. Marcogliese & Katherine S, 2024. "Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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