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Transcriptional activation of polycomb-repressed genes by ZRF1

Author

Listed:
  • Holger Richly

    (Centre de Regulació Genòmica (CRG)/UPF)

  • Luciana Rocha-Viegas

    (Centre de Regulació Genòmica (CRG)/UPF)

  • Joana Domingues Ribeiro

    (Centre de Regulació Genòmica (CRG)/UPF)

  • Santiago Demajo

    (Centre de Regulació Genòmica (CRG)/UPF)

  • Gunes Gundem

    (Universitat Pompeu Fabra)

  • Nuria Lopez-Bigas

    (Universitat Pompeu Fabra)

  • Tekeya Nakagawa

    (Nagasaki University School of Medicine)

  • Sabine Rospert

    (Institut für Biochemie und Molekularbiologie (ZBMZ), Universität Freiburg)

  • Takashi Ito

    (Nagasaki University School of Medicine)

  • Luciano Di Croce

    (Centre de Regulació Genòmica (CRG)/UPF
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Centre de Regulació Genòmica (CRG), PRBB, c/ Dr. Aiguader 88)

Abstract

ZRF1 role in cell fate decisions Ubiquitination of histone H2A has been implicated in polycomb-mediated transcriptional silencing, but its precise functions are unclear. Here, the phosphoprotein ZRF1 (zuotin-related factor 1) is shown to be recruited to ubiquitinated H2A and to function in displacing polycomb-repressive complex 1 (PRC1) from chromatin to facilitate transcriptional activation. This work suggests a molecular mechanism by which polycomb-repressed genes are switched to an active state and points to a key role for ZRF1 in determining cell fate.

Suggested Citation

  • Holger Richly & Luciana Rocha-Viegas & Joana Domingues Ribeiro & Santiago Demajo & Gunes Gundem & Nuria Lopez-Bigas & Tekeya Nakagawa & Sabine Rospert & Takashi Ito & Luciano Di Croce, 2010. "Transcriptional activation of polycomb-repressed genes by ZRF1," Nature, Nature, vol. 468(7327), pages 1124-1128, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09574
    DOI: 10.1038/nature09574
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    Cited by:

    1. Alessio Magis & Michaela Limmer & Venkat Mudiyam & David Monchaud & Stefan Juranek & Katrin Paeschke, 2023. "UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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