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Planar polarized actomyosin contractile flows control epithelial junction remodelling

Author

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  • Matteo Rauzi

    (IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy
    Present address: EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.)

  • Pierre-François Lenne

    (IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy)

  • Thomas Lecuit

    (IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy)

Abstract

Myosin-II in epithelial morphogenesis Myosin-II has a central role in generating the forces that drive cell shape changes during embryo development. Thomas Lecuit and colleagues study germ-band extension in Drosophila, in which epithelial cells undergo an ordered process of intercalation resulting in tissue extension through remodelling of cell junctions. They find that cell-junction shrinkage is driven by polarized flow of medial myosin-II pulses towards junctions, which organizes the whole process of intercalation. In addition, the flow of myosin-II is driven by the polarized distribution of E-cadherin/β-catenin/ α-catenin complexes at adherens junctions. Thus, epithelial morphogenesis is driven by polarized contractile actomyosin flows emerging from interactions between E-cadherin and actomyosin networks.

Suggested Citation

  • Matteo Rauzi & Pierre-François Lenne & Thomas Lecuit, 2010. "Planar polarized actomyosin contractile flows control epithelial junction remodelling," Nature, Nature, vol. 468(7327), pages 1110-1114, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09566
    DOI: 10.1038/nature09566
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    Citations

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    Cited by:

    1. Sijia Zhou & Peng Li & Jiaying Liu & Juan Liao & Hao Li & Lin Chen & Zhihua Li & Qiongyu Guo & Karine Belguise & Bin Yi & Xiaobo Wang, 2022. "Two Rac1 pools integrate the direction and coordination of collective cell migration," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Shun Li & Zong-Yuan Liu & Hao Li & Sijia Zhou & Jiaying Liu & Ningwei Sun & Kai-Fu Yang & Vanessa Dougados & Thomas Mangeat & Karine Belguise & Xi-Qiao Feng & Yiyao Liu & Xiaobo Wang, 2024. "Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Hiroyuki Uechi & Kazuki Fukushima & Ryota Shirasawa & Sayaka Sekine & Erina Kuranaga, 2022. "Inhibition of negative feedback for persistent epithelial cell–cell junction contraction by p21-activated kinase 3," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. R. Allena & J. Muñoz & D. Aubry, 2013. "Diffusion-reaction model for embryo development," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(3), pages 235-248.
    5. João Firmino & Jean-Yves Tinevez & Elisabeth Knust, 2013. "Crumbs Affects Protein Dynamics In Anterior Regions Of The Developing Drosophila Embryo," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-10, March.
    6. Alexis Villars & Alexis Matamoro-Vidal & Florence Levillayer & Romain Levayer, 2022. "Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Sanjay Karki & Mehdi Saadaoui & Valentin Dunsing & Stephen Kerridge & Elise Silva & Jean-Marc Philippe & Cédric Maurange & Thomas Lecuit, 2023. "Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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