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Gene expression divergence recapitulates the developmental hourglass model

Author

Listed:
  • Alex T. Kalinka

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany)

  • Karolina M. Varga

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
    Present address: New Biochemistry Building, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.)

  • Dave T. Gerrard

    (Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Stephan Preibisch

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany)

  • David L. Corcoran

    (Institute for Genome Sciences and Policy, Duke University)

  • Julia Jarrells

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany)

  • Uwe Ohler

    (Institute for Genome Sciences and Policy, Duke University)

  • Casey M. Bergman

    (Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Pavel Tomancak

    (Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany)

Abstract

The hourglass: a classic embryological model for the genomics age The appearance of embryos in related species converges midway through development and diverges thereafter, a phenomenon known as the developmental hourglass. The hourglass model builds on classic observations by Karl Ernst von Baer, later popularized by Ernst Haeckel — Charles Darwin's champion in Germany. But is this 'phylotypic stage' real? Two groups use contrasting methodology to test — and provide support for — the model. Genes expressed during the phylotypic stage are both evolutionarily older and more conserved across the genus than those expressed at other stages.

Suggested Citation

  • Alex T. Kalinka & Karolina M. Varga & Dave T. Gerrard & Stephan Preibisch & David L. Corcoran & Julia Jarrells & Uwe Ohler & Casey M. Bergman & Pavel Tomancak, 2010. "Gene expression divergence recapitulates the developmental hourglass model," Nature, Nature, vol. 468(7325), pages 811-814, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09634
    DOI: 10.1038/nature09634
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    Cited by:

    1. Mathilde Paris & Tommy Kaplan & Xiao Yong Li & Jacqueline E Villalta & Susan E Lott & Michael B Eisen, 2013. "Extensive Divergence of Transcription Factor Binding in Drosophila Embryos with Highly Conserved Gene Expression," PLOS Genetics, Public Library of Science, vol. 9(9), pages 1-18, September.
    2. Sara Ballouz & Risa Karakida Kawaguchi & Maria T. Pena & Stephan Fischer & Megan Crow & Leon French & Frank M. Knight & Linda B. Adams & Jesse Gillis, 2023. "The transcriptional legacy of developmental stochasticity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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