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A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns

Author

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  • Tomislav Domazet-Lošo

    (Max-Planck-Institut für Evolutionsbiologie, August-Thienemannstrasse 2, 24306 Plön, Germany
    Laboratory of Evolutionary Genetics, Ruđer Bošković Institute, Bijenička cesta 54, P.P. 180, 10002 Zagreb, Croatia)

  • Diethard Tautz

    (Max-Planck-Institut für Evolutionsbiologie, August-Thienemannstrasse 2, 24306 Plön, Germany)

Abstract

The hourglass: a classic embryological model for the genomics age The appearance of embryos in related species converges midway through development and diverges thereafter, a phenomenon known as the developmental hourglass. The hourglass model builds on classic observations by Karl Ernst von Baer, later popularized by Ernst Haeckel — Charles Darwin's champion in Germany. But is this 'phylotypic stage' real? Two groups use contrasting methodology to test — and provide support for — the model. Genes expressed during the phylotypic stage are both evolutionarily older and more conserved across the genus than those expressed at other stages.

Suggested Citation

  • Tomislav Domazet-Lošo & Diethard Tautz, 2010. "A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns," Nature, Nature, vol. 468(7325), pages 815-818, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09632
    DOI: 10.1038/nature09632
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    Cited by:

    1. Mirjana Domazet-Lošo & Tin Široki & Korina Šimičević & Tomislav Domazet-Lošo, 2024. "Macroevolutionary dynamics of gene family gain and loss along multicellular eukaryotic lineages," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    2. Wei Vivian Li & Yiling Chen & Jingyi Jessica Li, 2017. "TROM: A Testing-Based Method for Finding Transcriptomic Similarity of Biological Samples," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(1), pages 105-136, June.

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