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Glioblastoma stem-like cells give rise to tumour endothelium

Author

Listed:
  • Rong Wang

    (Memorial Sloan Kettering Cancer Center
    Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
    Brain Tumor Center, Memorial Sloan Kettering Cancer Center)

  • Kalyani Chadalavada

    (Molecular Cytogenetics, Memorial Sloan Kettering Cancer Center)

  • Jennifer Wilshire

    (Flow Cytometry Core, Memorial Sloan Kettering Cancer Center)

  • Urszula Kowalik

    (Memorial Sloan Kettering Cancer Center)

  • Koos E. Hovinga

    (Memorial Sloan Kettering Cancer Center
    Neurosurgical Center Amsterdam, Academic Medical Center)

  • Adam Geber

    (Memorial Sloan Kettering Cancer Center)

  • Boris Fligelman

    (Memorial Sloan Kettering Cancer Center)

  • Margaret Leversha

    (Molecular Cytogenetics, Memorial Sloan Kettering Cancer Center)

  • Cameron Brennan

    (Memorial Sloan Kettering Cancer Center
    Brain Tumor Center, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Viviane Tabar

    (Memorial Sloan Kettering Cancer Center
    Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center
    Brain Tumor Center, Memorial Sloan Kettering Cancer Center)

Abstract

Tumour cells that supply their own blood Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.

Suggested Citation

  • Rong Wang & Kalyani Chadalavada & Jennifer Wilshire & Urszula Kowalik & Koos E. Hovinga & Adam Geber & Boris Fligelman & Margaret Leversha & Cameron Brennan & Viviane Tabar, 2010. "Glioblastoma stem-like cells give rise to tumour endothelium," Nature, Nature, vol. 468(7325), pages 829-833, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09624
    DOI: 10.1038/nature09624
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    Citations

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    Cited by:

    1. Sree Deepthi Muthukrishnan & Riki Kawaguchi & Pooja Nair & Rachna Prasad & Yue Qin & Maverick Johnson & Qing Wang & Nathan VanderVeer-Harris & Amy Pham & Alvaro G. Alvarado & Michael C. Condro & Fuyin, 2022. "P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Lata Adnani & Jordan Kassouf & Brian Meehan & Cristiana Spinelli & Nadim Tawil & Ichiro Nakano & Janusz Rak, 2022. "Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Eunnyung Bae & Ping Huang & Gaёlle Müller-Greven & Dolores Hambardzumyan & Andrew Edward Sloan & Amy S. Nowacki & Nicholas Marko & Cathleen R. Carlin & Candece L. Gladson, 2022. "Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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